Unadjusted and adjusted estimates of HPV detection on incidence of other STIs (total number of visit pairs=3221)
| Detected with the following at previous visit | New cases of other STIs, n=46 (1.4%) n (row%) | New detection of other STIs across consecutive visits | ||
| Any HPV | ||||
| No | 2590 (80.4) | 31 (1.2) | 1.0 | 1.0 |
| Yes | 631 (19.6) | 15 (2.4) | 1.94 (1.05 to 3.58) | 1.81 (0.94 to 3.49) |
| New cases of other STIs, n=46 (1.4%) n (row%) | New detection of other STIs across consecutive visits | |||
| Any HR-HPV | ||||
| No | 2930 (91.0) | 38 (1.3) | 1.0 | 1.0 |
| Yes | 291 (9.0) | 8 (2.7) | 2.14 (1.00 to 4.61) | 2.00 (0.82 to 4.83) |
Estimates adjusted for age and study site at enrolment, as well as the following covariates assessed at each follow-up visit: pap smear diagnosis at previous visit, contraceptive use in last 6 months, number of lifetime partners, partners having sex with others in last 6 months, having new partner in last 12 months, male partner using condom in last 6 months.
Covariates that were found to be statistically significantly associated with the outcomes (p<0.05) and/or significantly influence the effect size of the primary association of interest (≥10%) were included in the final models for confounding control. Parity, smoking status, and other factors measured, such as age of sexual debut and frequency of sex in last 6 months,did not satisfy these criteria in the data analyses and hence werenot included in the final models.
HPV, human papillomavirus; HR-HPV, High-risk HPV, defined as HPV types 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66 (IARC 2007); STIs, sexually transmitted infections.