Table 1

Example of Trichomonas vaginalis (TV) candidate transmembrane proteins potentially mediating endocytosis*

Protein familyRefSeq accessionProtein length[FY]NPX[FY] motifAcidic cluster
BspAXP_001308117735NENPIFDDPFAADFMDS
BspAXP_0015843931092FTNPLFDDPFASDFDDP
BspAXP_001321489600YDNPFFDDPFASDFQND
BspAXP_001321493582YDNPFFDDPFASDFQND
BspAXP_001321496594FDNPLFDDPFASDFQNE
BspAXP_001321499447FDNPLFDDPFASDFQND
BspAXP_001321508733FDNPLYDDPFAKDFQNE
BspAXP_001323867405LDNPLFDDPFAEDFEEK
BspAXP_001328761549FSNPLFEDPFANDFEEG
BspAXP_0013287631142YINPLFDDPFASDFEDH
BspAXP_001328767834FTNPLFDDPFASDFEEH
BspAXP_001312366703ADNPIFDDPFAQDFNDD
PmpXP_001579443593NDNPLWDDPFRKDFEEE
PmpXP_001313554742DENPLWDDPFRNDFEEV
Pmp†XP_001325298624NDNPLWDDPFKKDFEEE
PmpXP_001306144569IDNPLWSDPFRTEFEEK
PmpXP_001582856712NDNPLWDDPFKNDFEED
Pmp†XP_001309734812NDNPLWDDPFKNDFEED
PmpXP_001328616605YTNPLWDDPFVDDFQEQ
PmpXP_001581046680NDNPLWDDPFKNDFEEE
PmpXP_001325882803NDNPLWEDPFKDDFNEI
PmpXP_001325146593QENPLWDDPFKGDFQEQ
PmpXP_001320330526NVNPLFDDPFRQDFEEK
PmpXP_0013203351819NDNPLWDDPFNNDFEED
Pmp†XP_001299221652NENPLWENPFLNDFEED

  • *Entries with at least one inferred transmembrane domain from two distinct TV protein families (BspA: Bacteroides surface protein A-like extracellular domain and Pmp: Chlamydia polymorphic membrane protein-like extracellular domain) but with a shared cytoplasmic tails possessing two motifs ([FY]NPX[FY] and acidic clusters) representing potentially signals for endocytosis—for details see ref. 11.

  • †Entries supported by cell surface proteomics.22