Table 1

Characteristics of the studies included in meta-analysis

StudyCountryStudy monthsSample sizeBlood sampled (n)ART typesDrug doseSubjects typesTransmission modesGenderMedian age (range), yearsJadad scale score
Choopanya et al 14 Thailand842413138TDFDailyPWIDNeedles/syringeBoth31 (20–60)5
Van Damme et al 4 Tanzania, South Africa, Kenya12205695TDF-FTCDailyWomenVaginalWomen24.2 (18–35)3
Molina et al 12 France, Canada24400113TDF-FTCIntermittentMSMRectalMen34.5 (NA)3
Grant et al 15 Peru, Ecuador, South Africa, Brazil, Thailand, USA31249943TDF-FTCDailyMSM and transgenderRectalMen27.1 (18–67)5
Baeten et al 16 Kenya, Uganda364747902TDF-FTCDailySerodiscordant couplesVaginal/penileBothNA (18–45)2
Baeten et al 16 Kenya, Uganda364747902TDFDailySerodiscordant couplesVaginal/penileBothNA (18–45)2
Baeten et al 31 Kenya, Uganda36441081TDF-FTCDailyserodiscordant couplesvaginal/penileBoth34 (28–40)2
Baeten et al 31 Kenya, Uganda364410149TDFDailySerodiscordant couplesVaginal/penileBoth33 (29–40)2
McCormack et al 32 England20544NATDF-FTCImmediateMSMRectalMen35 (NA)5
Thigpen et al 33 Botswana42121969TDF-FTCDailySexually active heterosexual adultsVaginal/penileBothNA (18–39)3
Marrazzo et al 3 South Africa, Uganda, Zimbabwe334969158TDFDailyWomenVaginalWomen25.3 (18–45)2
Marrazzo et al 3 South Africa, Uganda, Zimbabwe334969157TDF-FTCDailyWomenVaginalWomen25.3 (18–45)2
Peterson et al 34 Nigeria, Cameroon, Ghana12936NATDFDailyWomenVaginalWomen23.5 (18–34)5
  • ART,  antiretroviral therapy; PWID, people who inject drugs; MSM, men who have sex with men; NA, not available; FTC, emtricitabine; TDF, tenofovir disoproxil fumarate.