Displaying 1-10 letters out of 169 published
STIs and HIV in South Africa
In South Africa, a country that has battled with the HIV and TB co- epidemic for more than two decades, STI management has received little attention. We were delighted to read the article by Lurie et al, which highlights the high burden of STI syndromes in people living with HIV, in particular, in the period before ART initiation. While we concur with the authors' conclusions that systematic STI testing and treatment is warranted in HIV care programmes, the epidemiological data presented leave several unanswered questions.
There are major problems with reliance on syndromic management, particularly with the syndrome of vaginal discharge. STI symptoms poorly correlate with laboratory diagnoses, illustrated by gonorrhoea and chlamydia, which are mostly asymptomatic in women. Studies at the Centre for the AIDS Programme of Research in South Africa (CAPRISA) have shown a high prevalence of laboratory-diagnosed STIs in women at the time of acute HIV infection. Further analysis showed that clinical assessment alone missed 88% of laboratory-diagnosed STIs and 66% received unnecessary treatment .
Furthermore, the commonest cause of vaginal discharge is bacterial vaginosis (BV), an infection that is associated with sex, but does not appear to be sexually transmitted. We have found that over 50% of women had BV at HIV diagnosis which is often persistent . Lurie et al omit mentioning BV, perhaps misclassifying some of their findings.
While the authors' results are intriguing, a potential mechanism for the reduction of syndromic STIs on ART is missing. One could hypothesize that immunosuppression may increase the susceptibility and ability to clear STIs and BV. However, in this study the reduction in incidence was independent of CD4 count, in fact, the opposite was true, that a higher CD4 count was associated with more syndromic STI diagnoses. Alternative mechanisms namely behavioural change and length of clinical follow-up may have had a greater impact on the reduction of syndromic STI incidence than improvement in CD4 count in response to ART.
We hope, that the findings by Lurie et al and the following debate will contribute to the long overdue implementation of STI testing and treatment policies in South Africa.
Nigel Garrett and Adrian Mindel Centre for the AIDS Programme of Research in South Africa (CAPRISA)
1.Mlisana K, Naicker N, Werner L, Roberts L, van Loggerenberg F, Baxter C, et al. Symptomatic vaginal discharge is a poor predictor of sexually transmitted infections and genital tract inflammation in high- risk women in South Africa. J Infect Dis 2012,206:6-14.
Conflict of Interest:
Missing the path: time to reconceptualise STD prevention
The highlights of a strategy endorsed by the World Health Organization (WHO) in 2010 for Sexually Transmitted Infections (STI) screening, testing and early initiating into treatment (TnT) to Men that have Sex with Men (MSM) and transgender people are discussed by Cohen et al. in their editorial letter entitled "WHO guidelines for HIV/STI prevention and care among MSM and transgender people: implications for policy and practice" (1,2). In the same line as WHO, the authors call for improved access to STI screening services for people in low and middle- income settings regardless of their sexual identity, sexual orientation or their cultural and socioeconomic characteristics (1,2) Due to the higher prevalence of STI among these vulnerable groups, compared to the general population, the uptake of this guideline is recommended to prevent the transmission of STI and ensure that sexual minorities enjoy their right to access quality provision of STI healthcare (1,2).
The advantages of this strategy are understandable. This, regardless of the scarcity of data on the cost-effectiveness, cost-benefit and impact on community incidence of STI of routine TnT to asymptomatic MSM and transgender people that the WHO recommends (1). As the raison d'etre of a public health approach being informed by the evidence seems disregarded, in this letter we intend to highlight some gendered aspects that also derive from the WHO guideline and that, in our opinion, Cohen et al. may have given the same relevance as they had given to the WHO-endorsed TnT strategy.
STI screening is a secondary prevention strategy. In the scenario we are discussing, it may be assumed that all MSM and transgender people may eventually engage in sexual risky behaviours and, as consequence, be infected with an STI. Hence, the recommendation to screen those targets populations for STI even if asymptomatic. The pitfall of this recommendation is that these vulnerable groups may end up dealing with healthcare providers with prejudices towards them. The first assumption healthcare providers should have in mind is that these groups adhere to key messages on how to lead a healthy sexual life. Hence, Routine STI screening should not be the first step in the cascade to prevent, detect and treat STI. It can be ventured that STI TnT approach might result being less cost-effective, potentially more stigmatizing, and, more distanct from the goal of equity that the traditional primary prevention strategies hold (2,4).
On the other hand, women are not listed among the beneficiaries of this prevention strategy. The significance of understanding the motivations and other factors contributing to sexual risk taking among MSM that also have sexual intercourse with Women (MSMW) have been highlighted elsewhere (5,6,7). It must be acknowledged that in many low and middle- income countries, in order to fulfil with social expectations, many MSM may also engage, in an casual or in a permanent manner, in heterosexual relationships (7). To effectively reduce the community-level prevalence of STI, all asymptomatic women should also be targeted as beneficiaries of this TnT. In a context where cultural taboos and social stigma, judgemental attitudes from health workers towards sexual minorities, repressive policies, and anti-gay legislation, it is very unlikely that their MSMW might disclose to their female partners or their healthcare providers that they occasionally engage in unprotected same-sex sexual intercourse.
Fear to being stigmatized acts as a driving force that leads MSM to becoming MSMW, keeping their sexual orientation hidden, and hindering them from accessing and demanding STI healthcare. Acknowledging this leads us to another worrisome issue that should not be neglected from the umbrella of responsibilities that lie within the scope of the public health arena; how many countries with pandemic HIV/AIDS infection figures have actually decriminalized homosexuality in the last decade? According to the International Lesbian and Gay Association Report, there were 76 countries prosecuting people because of their sexual orientation as recent as in 2010. Eleven countries still include death penalty for homosexuals in their penal code (8). To effectively inform and carry out any health promotion campaign targeting MSM and transgender people, beyond advocating for the implementation of massive TnT strategies that capitalize the potential of new nucleid acid amplification testing technologies, the international community should move the focus to advocate for low and middle-income countries? governments to abolish their pre-colonial 'anti- sodomy laws', build the capacity of their healthcare providers to better address the health needs of MSM and transgender people, and raise awareness among the general population to respect the sexual rights of the most vulnerable ones (9,10).
A behavioural change approach, with the aim to promote adoption of safer sexual practices and an active demand of HIV/STI healthcare services, needs to be effectively integrated with any proposed TnT strategy. Health promotion is a basic public health tool that we find that it is not referred to in Cohen et al. missive. There is scientific evidence that behavioural change-based education, community awareness and advocacy approaches targeting sexual minorities may have a positive impact -even in budget-constrained settings- in terms of adoption of safer sexual practices with the ultimate goal to reduce incidence of HIV/STI (11). Why for Cohen et al. the cornerstone of the cascade of "solutions" to the high prevalence of STI may lie in targeted routine TnT when there is evidence on the benefits primary prevention strategies?.
From a primary prevention point of view, other approaches should be recommended. A public health approach to tackle HIV/STI is necessarily gendered. The structural gender system has to be taken into account, including in low and middle-income countries, when designing and endorsing these types of prevention strategies. It is crucial to understand how gender constructions are determinant in populations adopting sexual risk practices, in impeding or facilitating their access to HIV/STI diagnostic and treatment services, and in influencing government and institutional policy and decision making processes (12). To have a more comprehensive picture to inform approaches such as the STI TnT discussed in this letter, it can be suggested that other subjects such as "masculinities, transactional sex, infrastructural deficits in health and education (at all levels), fragile states and global governance" (13) should be studied and that sexual risk practices should be tackled in a broader context in which gender equity is pursued and stigma and discrimination are combatted.
1. Cohen J, Lo Y, Caceres CF, Klausner JD, for the WHO guideline working group. WHO guidelines for HIV/STI prevention and care among MSM and transgender people: implications for policy and practice. Sex Transm Infect 2013;89:536-538. 2. Gerbase A. Prevention and treatment of HIV and other sexually transmitted infections among men who have sex with men and transgender People: Recommendations for a public health approach. Geneva, Switzerland: WHO, Programme HIV/AIDS, 2011. Report No.: ISBN 978 92 4 150175 0. 3. Starfield B, Hyde J, Gerv?s J, Heath J. The concept of prevention: a good idea gone astray? J Epidemiol Community Health 2008;62:580-583. 4. Starfield B, Shi L, Macinko J. Contribution of Primary Care to Health Systems and Health. Milbank Quaterly 2005;83:457-502. 5. Maulsby C, Sifakis F, German D, et al. HIV risk among men who have sex with men only (MSMO) and men who have sex with men and women (MSMW) in Baltimore. J Homosex 2013;60:51-68. 6. Harawa NT, McCuller WJ, Chavers C, et al. HIV risk behaviours among Black/African American and Hispanic/Latina Female partners of men who have sex with men and women. AIDS Behav 2013;17:848-55. 7. Eaton LA, Pitpitan EV, Kalichman SC, et al. Men who report recent male and female sex partners in Cape Town, South Africa: an understudied and underserved population. Arch Sex Behav 2013;42:1299-308. 8. Ottoson D. State-Sponsored Homophobia. A world survey of laws prohibiting same sex activity between consenting adults. ILGA (International Lesbian, Gay, Bisexual, Trans and Intersex Association). 2010. 9. Joint United Nations Programme on HIV/AIDS (UNAIDS). UNAIDS Action Framework: Universal Access for Men who have Sex with Men and Transgender People. WHO Library Cataloguing-in-Publication Data. 2009. 10. Ripley J, Lauer K, Hebert P, et al. Speaking Out: A Toolkit for MSM- led HIV/AIDS Advocacy. Levi Strauss Foundation. The Global Forum on MSM and HIV (MSMGF). 2010. 11. McDaid LM, Hart GJ. Sexual risk behaviour for transmission of HIV in men who have sex with men: recent findings and potential interventions. Curr Opin HIV AIDS 2010;5:311-5. 12. Connell R. Gender, health and theory: Conceptualizing the issue, in local and world perspective. Social Science and Medicine 2012;74:1675- 1683. 13. Phillips AF, Pirkle CM. Moving beyond behaviour: advancing HIV risk prevention epistemologies and interventions (A report on the state of the literature). Glob Public Health 2011;6:577-92.
Conflict of Interest:
Response to 'Relative or Absolute? - Miller'
Responding to the editorial by Miller et al regarding the methodology of our study , we would challenge the assessment of the Zelen design as representing a form of 'deception'. Zelen design is employed to generate real life responses to help understand the translation challenges of introducing any similar or modified intervention across a whole area.
When general practices involved in our study were later informed of their participation none expressed concern. Qualitative work undertaken with these practices since the study has further confirmed they were supportive of the study design selected, and stated it reduced bias. Chlamydia data from general practice are routinely collected and published in England.
The editorial correctly identifies that levels of chlamydia screening within general practices in England is currently low. Viewed in this context, the 60% uptake generated by this intervention is significant. In terms of the increases in testing observed during and after the intervention period, our results were reported without inflation. Further, while the results from the intervention may be modest, repeated on a national scale a substantial increase in overall testing rates would be observed.
The National Chlamydia Screening Programme identifies general practice as an important venue through which opportunistic screening can be offered to young adults. We also know the most common form of contact young people have with medical services is with their GP. The results generated through our intervention represent a positive development in our understanding of how to increase screening in this setting. By engaging GPs in chlamydia screening, opportunities are created to discuss wider sexual health issues with young people, in a familiar and trusted surrounding.
We concur with Miller et al that changing practitioner behaviour is challenging. General practice is a complex environment where practitioner behaviour is subject to the influence of previous education and training, practice managers and partners, competing targets, and other priorities determined by the NHS. Other further research has shown that sustained support is important to maintain the impact of any multifaceted intervention, , and therefore Public Health England is continuing to provide such support. However, further research into how to sustain and maximise the impact of interventions to improve the sexual health service delivered in primary care would also be beneficial.
AUTHOR NAMES; Cliodna A M McNulty 1, Angela H Hogan 2, Ellie J Ricketts 3, Louise Wallace 5, Isabel Oliver 6, Rona Campbell 7, Sebastian Kalwij 8, Elaine O'Connell 4, Andre Charlett 9
1 Public Health England Primary Care Unit, Microbiology Department, Gloucestershire Royal Hospital, and Cardiff University, Cardiff, UK
2 (Previously) Public Health England Primary Care Unit, (Currently) Integrated Biobank of Luxembourg, Luxembourg, Luxembourg
3 Public Health England Primary Care Unit, Microbiology Department, Gloucestershire Royal Hospital
4 (Previously) Public Health England Primary Care Unit, (Currently) University of Bristol, Bristol, UK
5 Applied Research Centre Health & Lifestyle Interventions, Coventry University, Coventry, UK
6 Field Epidemiology Service, Public Health England, and University of Bristol, Bristol, UK
7 School of Social and Community Medicine, University of Bristol, Bristol, UK
8 Amersham Vale Training Practice, London, UK
9 Statistics, Modelling and Economics Department, Public Health England, 61 Colindale Avenue, London, UK
Miller W, Nguyen N. Relative or Absolute? A significant intervention for chlamydia screening with small absolute benefit. Sex Transm Infec [Editorial -in print] 2014
McNulty C a M, Hogan AH, Ricketts EJ, Wallace L, Oliver I, Campbell R, et al. Increasing chlamydia screening tests in general practice: a modified Zelen prospective Cluster Randomised Controlled Trial evaluating a complex intervention based on the Theory of Planned Behaviour. Sex Transm Infec [Internet]. 2013 Sep 4 [cited 2013 Oct 23];1-7. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24005256
Shafer M-AB, Tebb KP, Pantell RH, Wibbelsman CJ, Neuhaus JM, Tipton AC, et al. Effect of a clinical practice improvement intervention on Chlamydial screening among adolescent girls. JAMA?: J. Amer Med Assoc. 2002 p. 2846-52.
Kalwij S, French S, Mugezi R, Baraitser P. Using educational outreach and a financial incentive to increase general practices' contribution to chlamydia screening in South-East London 2003-2011. BMC public health [Internet]; 2012 Jan [cited 2013 Oct 23];12(1):802. Available from: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=3524034&tool=pmcentrez&rendertype=abstract
PHE National Chlamydia Screening Programme (NCSP) website; http://www.chlamydiascreening.nhs.uk/ps/index.asp accessed on 8th April 2014
Conflict of Interest:
All authors have completed the Unified Competing Interest form at http://www.icmje.org/coi_disclosure.pdf (available on request from the corresponding author) and declare that '(1) CM, ER, AH, LW, RC, IS, EO, SK, AC have support from the Public Health England for the submitted work. Dr Cliodna McNulty leads the Public Health England Primary Care Unit that has an ongoing programme of work aimed at improving the management of infectious disease in primary care. Public Health England leads the National Chlamydia Screening Programme in England.
Promoting HIV testing, chlamydia testing and long acting reversible contraception.
Phillips and colleagues found a third of in-patients had HIV tests following implementation of a routine HIV testing policy at Croydon University Hospital1. We recently found similar rates of HIV testing in young women in the community in our medical student research projects. In line with the 2013 Framework for Sexual Health Improvement's "three specific indicators for sexual health" 2, we investigated reported uptake of HIV testing, chlamydia testing and long acting reversible contraception (LARC) in young women attending a further education college and a university in London.
In September 2013 consecutive women in common room areas were invited to complete a confidential questionnaire on sexual health. The response rate among women at Lambeth College was 78% (77/99). The mean age of responders was 18 years (range 16-24), and 43% described themselves as being of black ethnicity, 19% white, and 38% of other ethnicity. Of the 39 (51%) women who said they were sexually active, 51% (20/39) had been tested for HIV in the past year and 78% (28/36) for chlamydia. A third (13/39) were currently using LARC (implant n=10, injection n=3).
The response rate among women at London Southbank University was 92% (79/86). The mean age of responders was 21 years (range 18-25) and 38% were from ethnic minorities. In the past year, 32% (25/79) had been tested for HIV and 34% (26/77) for chlamydia. Only 5% (4/79) reported the use of LARC in the past year, all of these being the implant. We agree with Phillips and colleagues that late diagnosis of HIV is a major public health problem. The recent Natsal report found that 29% of women but only 14% of men aged 16-24 years reported being tested for HIV in the past 5 years 3. Although rates of HIV testing in sexually active, multiethnic young women in our study were encouraging, it is also crucial to promote HIV testing in young men.
Anne Tear and Jessica Herbert 3rd year Medical Students Pippa Oakeshott Reader in General Practice Population Health Sciences and Education, St George's, University of London Correspondence: email@example.com, firstname.lastname@example.org Acknowledgement We thank students and staff at Lambeth College and London Southbank University.
Reference List (1) Philips. D, Barbour. A, et al, Implementation of a routine HIV testing policy in an acute medical setting in a UK general hospital: a cross sectional study, STI 2013, doi: 10.1136/sextrans-2013-051302 (2) Department of Health, Improving outcomes and supporting transparency, November 2013, pg 53, 91,99 https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/263662/2901502_PHOF_Improving_Outcomes_PT2_v1_1.pdf [Acessed 13th December 2013] (3) Sonnenberg P, Clifton S, Beddows S, et al, Prevalence, risk factors, and uptake of interventions for sexually transmitted infections in Britain: findings from the National Surveys of Sexual Attitudes and Lifestyles (Natsal), The Lancet, Volume 382, Issue 9907, Pages 1795 - 1806, 30 November 2013 doi:10.1016/S0140-6736(13)61947-9
Conflict of Interest:
Trichomonas Vaginalis (TV) is frequently described as being associated with pre-term delivery and low birth weight - and was again by Professor Hillier in her editorial in her (unreferenced) introductory paragraph. As far as I can ascertain, this association appears to be based on published evidence from the 80s and 90s.
Is it possible, given the more recent understanding of a link between TV and poverty, that these 20 year old studies were confounded?
There is conflicting evidence as to whether the use of metronidazole is itself associated with worse birth outcomes1,2 and so it is important to have a full understanding of the role of TV.
In global terms I work and teach in a setting with a low prevalence of HIV. Can anyone help me find reasonably strong evidence that TV is other than a harmless commensal for those of my patients who are asymptomatic?
1.What have we learned about vaginal infections and preterm birth? Carey JC et al Semin Perinatol 2003 27(3):212-6 2. Investigation of metronidazole use during pregnancy and adverse outcomes Catherine A Coss et al Antimicrobial Agents and Chemotherapy 2012 56(9) 4800-5
Conflict of Interest:
Response to a letter Recent Advances of the HIV Surveillance System in Iran: Current Situation and Ways Forward
We very much appreciate the letter that Dr Haghdoost and colleagues wrote in relation to some of the issues outlined in our paper HIV surveillance in MENA: recent developments and results and, in addition, described some more recent developments in HIV surveillance in Iran.
We would like to reflect on several issues that they raised.
Our paper states that Djibouti, Iran, Morocco and Pakistan can be classified as having fully functioning HIV surveillance systems as trends in HIV prevalence in these countries can be assessed over time for certain population sub-groups. Surveillance systems in these countries have a sufficient quantity and quality of the data that can be used to guide the programmatic responses. We also mentioned other nine countries that have partially functioning HIV surveillance systems.
As described in the Methods section of our paper, the assessment of the quality of HIV surveillance systems was based on the questionnaire sent to National AIDS Programmes (NAPs) of the countries of the WHO Eastern Mediterranean Region (EMR) in 2009, 2010 and 2011, and not on the data presented in the paper by Garcia Calleja et al published in Sexually Transmitted Infections in 2010. As described in our paper, to assess the quality of HIV surveillance systems we adapted a method developed by WHO and UNAIDS.123
As one of the limitations, we outlined that data were provided by the NAPs, which might have missed data sources collected by other agencies that Haghodoost et al. mention, such as surveys in partners of IDUs. However, as planning of surveillance and programmatic responses is lead by the NAPs, we think that collecting data from NAPs gives an appropriate insight into the type and quality of data that the countries use for planning and evaluating the national HIV response. We are aware that many studies might be undertaken in the EMR, but their results are not disseminated, and this is particularly the case with studies done in groups at higher risk of HIV that are heavily stigmatized.
In relation to some other issues that the colleagues raised, surveys using respondent-driven sampling were done in many other countries in the Region (some of these are referenced in the paper) as well as Mode of Transmission studies.4
We have not reflected on the reasons for the improvements in HIV surveillance in North Africa and the Middle East, but we believe this has been due to greater availability of funding provided by the Global Fund to Fight AIDS, Tuberculosis and Malaria and capacity building efforts of numerous international and national agencies.
We agree with Dr Haghdoost and the colleagues that there are substantial improvements in HIV surveillance in Iran though significant challenges remain in bridging the gaps that the system still has. One of them is certainly in conducting studies on HIV and sexually transmitted infections in MSM and transgendered individuals, which due to prevailing stigmatization are still lacking throughout the Region.
1. Garcia Calleja JM, Jacobson J, Garg R, et al. Has the quality of serosurveillance in low- and middle-income countries improved since the last HIV estimates round in 2007? Status and trends through 2009. Sex Transm Infect 2010;86(Suppl 2):ii35-42
2. Walker N, Garcia-Calleja JM, Heaton L, et al. Epidemiological analysis of the quality of HIV sero-surveillance in the world: how well do we track the epidemic? AIDS 2001;15:1545-54
3. Lyerla R, Gouws E, Garcia-Calleja JM. The quality of sero- surveillance in low- and middle-income countries: status and trends through 2007. Sex Transm Inf 2008;84: i85-91.
4. Mumtaz G, Hilmi N, Zidouh A, El Rhilani H, Alami K, Bennani A, Gouws E, Ghys P, Abu- Raddad L. HIV Mode of Transmission Analysis. Rabat: Kingdom of Morocco. Ministry of Health, Department of Epidemiology and Disease Control, 2010.
Conflict of Interest:
Recent Advances of the HIV Surveillance System in Iran; Current Situation and Ways Forward
We very much enjoyed reading Dr. Bozicevic's paper about the recent developments in HIV Surveillance in MENA in a recent issue of your journal . Some topics discussed in that paper concern us and we would like to share a few opinions about the current HIV surveillance system in Iran and its recent advances. In the paper it is stated that only two countries in the region (Morocco and Sudan) have a partially functioning HIV surveillance; however, we assume this is based on the data presented in a study conducted in 2009  and at present, Iran has also a somewhat functioning HIV surveillance system. For example, Iran has done a pretty fine job in controlling the HIV infection among IDUs and monitoring the epidemic trend in pregnant women . Iran has been also conducting biannual bio-behavioral surveys among IDUs, FSWs, IDU partners, and prisoners . More recently, size estimation programs have been introduced to the system and we have conducted size estimation studies in estimating the size of at risk populations . On top of the above, Iran is one the only countries in the region that has conducted Respondent Driven Sampling as well as Mode of Transmission studies [3, 5]. What is more, the number of HIV/AIDS related publications in Iran (in PubMed database) has doubled in a five- year period which is also an evidence of improvement of the system . We think a number of reasons may have contributed to this progress. The role of the Regional Knowledge Hubs in HIV/AIDS Surveillance in educating healthcare providers and researchers as well as health policy makers cannot be ignored . These educations have been given through national and international workshops and sending out educational packages to different policy makers, from members of the parliament to those in the presidential office. We assume highlighting the burden of HIV/AIDS in the upcoming years has been successful in drawing policy makers' attention to the seriousness of the HIV epidemic across the country in a way that controlling HIV/AIDS throughout the country was a serious concern in the recent presidential debates. Despite all the achievements in addressing the HIV epidemic, there is still a lot to be done and the current system still suffers to a considerable extent. For example, likewise most countries in the region, MSM and transgendered populations have long been overlooked in the HIV surveillance system; ignorance mainly originated from the stigma surrounding such populations. We think one of the main challenges to be overcome is the pitfalls in the case finding and reporting system of Iran. The sensitivity of case finding in Iran is low and following up the HIV patients and assessing their adherence to therapy is a major challenge in front of healthcare providers [5, 8]. Although the case reporting system is not fully functioning, a national computer-based is being launched in the country that opens a window of hope in fixing the defects in the current reporting system. The Ministry of Health is really optimistic about this system; however, its effectiveness is yet to be evaluated.
References: 1. Bozicevic I, Riedner G, and Garcia Calleja JM. HIV surveillance in MENA: recent developments and results. Sex Transm Infect, 2013. online: p. 1-6. 2. Garc?a Calleja JM, Jacobson J, Garg R, et al. Has the quality of serosurveillance in lowand middle-income countries improved since the last HIV estimates round in 2007? Status and trends through 2009. Sex Transm Infect, 2010. 86 (Suppl 2): p. 35-42. 3. National AIDS Committee Secretariat and Ministry of Health and Medical Education. Islamic Republic of Iran AIDS Progress Report On Monitoring of the United Nations General Assembly Special Session on HIV and AIDS.2012, available at: www.unaids.org/en/dataanalysis/knowyourresponse/countryprogressreports/IRiran,1.PDF2012. 4. Shokuhi M, baneshi MR and haghdoost AA. Size Estimation of Groups at High Risk of HIV/AIDS using Network Scale Up in Kerman, Iran. Int J Prev Med, 2012 .3(7): p. 471-476. 5. Nasirian M, Doroudi F, Gooya MM, et al. Modeling of Human Immunodeficiency Virus Modes of Transmission in Iran. Journal of Reaserch in Health Sciences, 2012. 12(2): p. 81-87. 6. Saba HF, Kouyoumjian SP, Mumtaz GR, et al. Characterising the progress in HIV/AIDS research in the Middle East and North Africa. Sex Transm Infect, 2013. online: p. 1-5. 7. Mostafavi E, Haghdoost AA, mirzazadeh A, et al. Regional HIV knowledge hubs: a new approach by the health sector to transform knowledge into practice. Health Promotion International, 2012. online: p. 1-7. 8. Haghdoost AA, Mostafavi E, Mirzazadeh A, et al. Modelling of HIV/AIDS in Iran up to 2014. Journal of AIDS and HIV Research Journal of AIDS and HIV Research, 2011. 3(12).
Conflict of Interest:
Measures of risk do not discriminate between MSM tested for HIV within the previous 6 months and MSM tested 6 to 12 months previously: Data from Glasgow, Scotland, in 2010.
UK and USA guidelines recommend at least annual HIV testing for men who have sex with men (MSM), with more frequent testing for those at risk. Although measures of risk and regularity of HIV testing are essential for evaluating interventions, these are not yet standardised across the UK.1 Risk criteria could include recent unprotected anal intercourse (UAI), a high number of partners, unknown partners, and recent STI.2 From self- report data collected in Glasgow with a bar-based sample (excluding non- Scottish and HIV positive men, n = 683), we compared two groups on these risk criteria, in addition to demographic variables and psychosocial testing barriers. The groups were those reporting an HIV test within the previous 6 months (recent testers) and those reporting a test 6-12 months previously.
Recent testers (39.7%, n = 271) and those tested 6-12 months previously (17.6%, n = 120) differed significantly on the number of sexual partners reported in the previous year; those tested 6-12 months previously were more likely to report only 0-1 sexual partner, while recent testers were more likely to report 2-10 partners: ??2 (2) = 6.33, p = .042. However, the proportions of those reporting ?11 partners were almost identical: 22.5% and 22.9% respectively. The groups did not differ significantly on the numbers of UAI partners in the previous year. Among those with at least one UAI partner, the groups did not differ on status of partners (casual or regular), knowledge of the partners' HIV status, or whether those partners were HIV positive. There was a non- significant trend (p = .094) for recent testers to report STI in the previous year. The groups did not differ on demographic characteristics (age, employment, education, use of the gay scene) or barriers to HIV testing (benefits, fear, clinic barriers, attitudes to sex with HIV positive partners, testing norm).
Most measures of risk did not differentiate between the two groups of testers, suggesting further research on the measurement of risk and frequency or regularity of testing is warranted. We are exploring the utility of including measures of regularity and frequency of HIV testing in our surveys: one of the limitations of the analysis reported here (in addition to reliance on self-reported and cross-sectional data from a bar- based sample) was the use of a retrospective measure of the most recent HIV test.
ACKNOWLEDGEMENTS The survey was funded by NHS Greater Glasgow & Clyde, Ayrshire & Arran and Lanarkshire. The MRC funds Dr Lisa McDaid.
ETHICS APPROVAL Granted by the Psychology Ethics Subcommittee at Glasgow Caledonian University.
1. Desai M, Desai S, Sullivan AK, et al. Audit of HIV testing frequency and behavioural interventions for men who have sex with men: policy and practice in sexual health clinics in England. Sex Transm Infect. Published Online First: January 7, 2013. doi:10.1136/sextrans- 2012- 050679.
2. Katz DA, Dombrowski JC, Swanson F, et al. HIV intertest interval among MSM in King County, Washington. Sex Transm Infect 2013;89:32-37. doi:10.1136/sextrans-2011-050470.
Conflict of Interest:
Why is the Number of HIV/AIDS Related Publications Low in the MENA Region?
We enjoyed reading Dr. Saba's paper and would like to share some opinions about HIV/AIDS related publications in the Middle East and North Arica (MENA). This paper showed a positive trend in the number of annual HIV/AIDS related publications in the MENA, on the other hand, this paper suggests that this number is still very low considering the sharp upward trend of HIV new infections in this region. This gap might be due to several factors. The unsupportive dominant political climate as well as the stigma and sensitivity surrounding at- risk populations such as Men having Sex with Men is very high. Some of these countries have long been struggling with internal wars, uprisings, and terrorism; that may overshadow the importance of this infection in the minds of those in charge.
On the other hand, the dynamic of research have profound pitfalls in the region. The potential research capacity and the availability of funding do differ greatly across the region. Lack of a clear and comprehensive plan in several countries in this region might also be an influencing factor. Last but not least, scarce publications on HIV/AIDS related topics may stem from the policy of credited scientific journals in publishing the findings of researchers from this region. Most scientific journals stick to high international research standards (regarding methodology mainly), while reviewing manuscripts from the MENA region. Some barriers such as low sample size, presence of selection and information biases to some extent might convince journals to reject the papers from this region. However, implementation of high quality studies might be impossible in some of these countries. We think even simple descriptive data using even convenience sampling methods could be an important step forward in enriching the available data in the region. Out of the formerly mentioned factors, we assume changing the viewpoints of journal editors is one of the most feasible options we have ahead. Lastly, although publishing the findings of researches and studies across the region is of importance, the way and to the extent those findings are applied in the countries to make a change and better the situation is much more vital.
References: 1. Hanan F Saba, et al., Characterising the progress in HIV/AIDS research in the Middle East and North Africa. Sex Transm Infect, 2013(0): p. 1-5. 2. Ivana Bozicevic, Gabriele Riedner, and Jesus maria Garcia Calleja, HIV surveillance in MENA: recent developments and results. Sex Transm Infect, 2013(0): p. 1-6. 3. Ghina R Mumtaz, et al., Are HIV epidemics among men who have sex with men emerging in the Middle East and North Africa?: a systematic review and data synthesis. PLoS Med, 2011. 8(8): p. e1000444.
Conflict of Interest:
Chlamydia testing: where are we now? Recruiting high risk women to a pilot STI screening trial.
In their topical editorial, Jain and Ison state that "testing (for chlamydia) is a crucial part of any effective control strategy"1. In January 2013 we conducted a pilot study of Chlamydia trachomatis and Neisseria gonorrhoea testing in female students at Lambeth Further Education College, London to assess recruitment to a possible POPI (prevention of pelvic infection) 2 screening trial.2
Two female general practitioners approached consecutive female students in the common room and asked them to help with a women's health study. We explained that only women aged 16-27 who were sexually experienced were eligible. Those who consented completed a questionnaire and provided a self-taken vaginal swab. We explained that as samples might not be tested for six months, it was participants' responsibility to get tested independently if they were at risk of STIs. Subjects were given a small honorarium (?5 and a lollipop) when they returned the samples.
Of 40 women approached, eight were aged >27 and seven refused: response rate 78% (25/32). Responders were broadly similar to non- responders in the proportion of black ethnicity (56%, 14/25 versus 86%, 6/7) but were younger (mean (sd) 19.3 (2.7) years versus 22.9 (3.5) years, p<0.01)). Unlike our difficulties in the POPI trial2, we recruited our target of 25 women in 90 minutes and had to turn away potential participants as we had run out of packs. Three women were later excluded as their questionnaire responses showed they had never had sex. Of the 22 sexually active women, 41% reported two or more sexual partners in the previous year and 45% were smokers. Mean age of sexual debut was 15.5 years (range 13 to 19). Four women reported a history of STI.
Within a week, samples were randomly allocated to immediate or deferred testing. Two of 16 participants in the immediate testing group were positive - one for chlamydia and one for gonorrhoea. They were easily contactable by mobile phone and email and referred for treatment. We will return to the college in six months to request a further vaginal swab and questionnaire from the 22 eligible participants. Although we need to ensure only those who are sexually experienced are recruited, our study suggests small financial incentives may be useful.
Ethics review: Bromley REC: 12/LO/0855
Acknowledgements: We thank students and staff at Lambeth College.
1. Jain A, Ison CA. Chlamydia point-of-care testing: where are we now? Sex Transm Infect 2013;89(2)88-89.
2. Oakeshott P, Kerry S, Aghaizu A et al. Randomized control trial of screening for Chlamydia trachomatis to prevent pelvic inflammatory disease: the POPI (prevention of pelvic infection) trial. BMJ. 2010;340:c1642
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