Regular ArticleTransmission of Human Immunodeficiency Virus Type 1 (HIV-1) from Mother to Child Correlates with Viral Phenotype
References (0)
Cited by (127)
The evolution of hiv-1 interactions with coreceptors and mannose C-type lectin receptors
2015, Progress in Molecular Biology and Translational ScienceCitation Excerpt :Moreover, several strains of CXCR4-using SHIVs readily infect macaques via different routes (reviewed in Ref. 51). Although R5 viruses are predominately detected in children infected by their mothers, it is not uncommon that CXCR4-using strains are identified early after birth.52,53 Thus, the transmission of CXCR4-using viruses appears to be more frequent in vertical transmission than in other routes of transmission (reviewed in Ref. 54).
HIV-1 envelope-dependent restriction of CXCR4-using viruses in child but not adult untransformed CD4<sup>+</sup> T-lymphocyte lines
2012, BloodCitation Excerpt :Phylogenetic analyses of gp120 Env sequences have demonstrated that CXCR4-using viruses in children did not derive from the maternal population of HIV-1 quasispecies but were consequent to the intrahost evolution of an originally transmitted homogeneous R5 HIV-1. Furthermore, although mothers harboring CXCR4-using viruses showed a significantly higher risk of transmitting the infection to their children than those infected by R5 viruses,15 in most cases the transmitted virus was an R5 strain.15,16 Thus, R5 HIV-1 both in adults17 and children is clearly better fit to be transmitted and spread in immunocompetent hosts than CXCR4-using viruses, although these latter may emerge once the immune system is severely compromised.
The evolution of human immunodeficiency virus type-1 (HIV-1) envelope molecular properties and coreceptor use at all stages of infection in an HIV-1 donor-recipient pair
2012, VirologyCitation Excerpt :The main coreceptors used by HIV-1 in vivo are the chemokine receptors CCR5 and CXCR4 (De Roda Husman et al., 1999; Deng et al., 1996; Dragic et al., 1996; Feng et al., 1996). CCR5-using (R5) viruses predominate in the early stages of HIV-1 infection irrespective of the route of transmission (Casper et al., 2002; Husson et al., 1995; Keele et al., 2008; Salazar-Gonzalez et al., 2008; Scarlatti et al., 1993; Van 't Wout et al., 1994) and persist throughout the course of the disease (Connor et al., 1997; Scarlatti et al., 1997; Schuitemaker et al., 1992). The biological properties of R5 viruses commonly evolve throughout the natural course of infection (Jansson et al., 1996, 1999; Koning et al., 2003; Kwa et al., 2003; Repits et al., 2005).
Adaptive evolution in perinatal HIV-I
2005, Best Practice and Research: Clinical Obstetrics and GynaecologyCitation Excerpt :Some phenotypic characteristics, based on the envelope (external) characteristics of the virus, appear to suggest selective (tropic) processes are involved in mother-to-child transmission of HIV-1, but there are contradictory reports in almost all cases. Rapidly replicating isolates capable of inducing syncytia in T-cell lines are better transmitted71, but viruses with high replication rates in monocyte-derived macrophages59 which are non-syncytium-inducing72 appear to be important too. For the envelope and internal genes studied, a homogenous or diverse population may be detected in the infant early on (Table 4).
Zidovudine monotherapy and the prevention of mother-to-child HIV-1 transmission
2005, Lancet Infectious DiseasesAmniotic fluid has higher relative levels of lentivirus-specific antibodies than plasma and can contain neutralizing antibodies
2004, Journal of Clinical Virology