Skip to main content
Log in

Comparative study of systemic Interferon alfa-2a with oral isotretinoin and oral isotretinoin alone in the treatment of recurrent condylomata accuminata

  • Originals
  • Published:
Archives of Gynecology and Obstetrics Aims and scope Submit manuscript

Abstract

Objectives: We attempted to test the hypothesis that the combination of systemic interferon alfa-2a and oral isotretinoin is more effective than isotretinoin alone in the treatment of recurrent condylomata accuminata.Study design: Fifty seven women with recurrent condylomata accuminata were randomly assigned in two groups. Group A (n = 24) received isotretinoin alone (Roaccutan, Roche) 1 mg/kgr orally daily for 3 months or until a remission was achieved; Group B (n = 33) received Interferon alfa-2a (Roferon-A, Roche) 3 million units subcutaneously three times for 8 weeks plus isotretinoin 1 mg/Kg orally for 3 months or until a remission was achieved.Results: There was no statistically significance in remission rates between the two groups (18/24 vs 28/33,p > 0.1). However the duration of treatment was statistically significantly shorter in Group B (1.9 vs 2.5 months,p < 0.01). Side effects were minimal.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Alberts DS, Coulthard SW, Meyskens FL (1986) Regression of aggressive laryngeal papillomatosis with 13-cis-retinoic acid (Accutane). J Biol Response Med 5:124–128

    Google Scholar 

  • Bertram JS, Martner JE (1984) Retinoids as inhibitory of neoplastic transformations in vitro: mechanistic studies. In: Saurat JH (ed) Retinoid Symposium. Basel: Karger

    Google Scholar 

  • Borden EC, Ball LA (1981) Interferons: biochemical, cell growth inhibitory and immunological effects. Prog Hematol 12:299–339

    PubMed  Google Scholar 

  • Boutwell RK, Verma HK, Loprinzi CM, Carbone PP (1984) Retinoids as inhibitors of tumor promotion. In: Saurat JH (ed) Retinoid Symposium, Basel: Karger

    Google Scholar 

  • Boyle J, Dick DC, Mackie RM (1983) Treatment of extensive virus warts with etretinate (Tegison) in a patient with sarcoidosis. Clin Exp Dermatol 8:33–36

    PubMed  Google Scholar 

  • Cardamakis E, Deligeorouglou E, Hassan E, Creatsas G, Aravantinos D (1991a) Treatment of recurrent condylomata accuminata with etetrinate (Tigason, Roche): preliminary report in 13 adolescents. In: Advances on pediatric and adolescent gynecology, Athens, December 13–14. Book of Abstract, p 2

  • Cardamakis E, Korantzis A, Relakis K, et al. (1991b) Treatment of flat or accuminata condylomata and cervical intraepithelial neoplasia with interferon alpha-2a, Laser CO2 (vaporization, cone) and 5-fluorouracil 5% (5-FU). EJC (Abstract) 5 [Suppl. 2]:219

    Google Scholar 

  • Claudy AL, Touraine GL, Mitanne D (1982) Epidermodysplasia verruciformis induced by anew human papillomavirus (HPV-8). Arch Dermatol Res 274:213–219

    PubMed  Google Scholar 

  • Claudy AL, Rouchouse B (1984) Treatment of cutaneous T-cells lymphomas with synthetic retinoids. In: Saurat JH (ed) Retinoid Symposium. Basel: Karger

    Google Scholar 

  • Connor MJ, Lowe NJ (1984) Retinoid stimulation of epidermal cell growth in vivo. In: Saurat JH (ed) Retinoid symposium. Basel: Karger

    Google Scholar 

  • Deligeoroglou E, Cardamakis E, Hassan E, Creatsas G, Aravantinos D (1992) Comparative study of systemic interferon alfa-2a plus etetrinate vs etetrinate in the treatment of recurrent condylomata accuminata: preliminary report in 33 adolescents. Adolesc Pediatr Gynecol (Abstract) 5:125

    Google Scholar 

  • Dicken Ch, Connolly SM (1982) Systemic retinoids in dermatology. Mayo Clinic Proc 57:51–53

    Google Scholar 

  • Douglas Jr JM, Rogers M, Jutson FN (1986) The effect of asymptomatic infection with HTLV-III on the response of anogenital warts to intralesional treatment with recombinant alpha-2a interferon. J Infect Dis 154:331–334

    PubMed  Google Scholar 

  • Elias PN, Williams ML (1984) Retinoid effect on epidermal structure, differentiation and permeability. In: Saurat JH (ed) Retinoid symposium. Basel: Karger

    Google Scholar 

  • Ferenczy A, Mitao M, Nagai N, Silverstein SJ, Crum CP (1985) Latent papillomavirus and recurring genital warts. N Engl J Med 313:784–788

    PubMed  Google Scholar 

  • Gross G, Pfister H, Hagedorn M, Stahn R (1983) Effect of oral aromatic retinoid (Ro 10-9359) on human papillomavirus-2-induced common warts. Dermatologica 166:48–53

    PubMed  Google Scholar 

  • Jablonska S, Obalek S, Wolska H, Jazzabek-Chozzelska M (1981) Ro 10-9359 in epidermodysplasia verruciformis. Preliminary report. In: Orfanos CE, Braun-Falco O, Farber EM, Grupper Ch, Polano MK, Schuppli R (eds) Retinoids advances in basic research and therapy. Berlin: Springer, p 401

    Google Scholar 

  • Lippman S, Kavanagh J, Paredes-Espinoza M, et al. (1992) 13-cis-Retinoic acid plus interferon-2a: highly active systemic therapy for squamous cell carcinoma of the cervix. J Natl Cancer Inst 84:241–245

    PubMed  Google Scholar 

  • Lotan R (1984) Mechanism of inhibition of tumor cell proliferation by retinoids: studies with cultured melanoma cells. In: Saurat JH (ed) Retinoid Symposium. Basel: Karger

    Google Scholar 

  • Lutzner MA (1981) Oral retinoid treatment of human papillomavirus type 5-induced epidermodysplasia verruciformis. N Engl J Med 302:1091–1093

    Google Scholar 

  • Lutzner MA (1983) The human papillomaviruses. Arch Dermatol 119:631–635

    PubMed  Google Scholar 

  • MacGuire J, Fedarko N, Joannsenn E (1982) The influence of retinoids on cultivated human keratinocytes. J Am Acad Dermatol [Suppl.] 6:630–639

    PubMed  Google Scholar 

  • Meyskens FL (1982) Studies of retinoids in the prevention and treatment of cancer. J Am Acad Dermatol [Suppl.] 6:824–827

    PubMed  Google Scholar 

  • Molin L, Thomsen K, Volden G, Wantzin GL, Hellbe L (1984) 13-cis retinoid acid-effective treatment in mycosis fungoides. In: Saurat JH (ed) Retinoid Symposium. Basel: Karger

    Google Scholar 

  • Moon RC, MacCormick DL (1982) Inhibition of chemical carcinogenesis by retinoids. J Am Acad Dermatol [Suppl.] 6:809–814

    PubMed  Google Scholar 

  • Munkvad M, Geuner J, Staberg B, Kongsholm H (1983) Locally injected bleomycin in the treatment of warts. Dermatologica 167:86–89

    PubMed  Google Scholar 

  • Olsen E, Kelly F, Vollmer R, Buddin D, Week P (1989) Comparative study of systemic interferon alfa-2a and isotretinoin in the treatment of resistant condylomata accuminata. J Am Acad Dermatol 20:1023–1030

    PubMed  Google Scholar 

  • Peck GL, Gross EG, Butky D, DiGiovanna JJ (1982) Chemoprevention of basal cell carcinoma with isotretinoin. J Am Acad Dermatol [Suppl.] 6:815–823

    PubMed  Google Scholar 

  • Peck GL (1984) Therapy and prevention of skin cancer. In: Saurat JH (ed) Retinoid Symposium. Basel: Karger

    Google Scholar 

  • Pigatto PD, Bersani L, Nobile G, De Luca A, De Blasio A, Altanare GF (1984) Effect of retinoid administration on natural killer cell activity. In: Saurat JH (ed) Retinoid Symposium. Basel: Karger

    Google Scholar 

  • Pittsley RA, Yoder FW (1983) Retinoid hyperostosis. Skeletal toxicity associated with long-term administration of 13-cis-retinoic acid for refractory icthyosis. N Engl J Med 308:1012–1014

    PubMed  Google Scholar 

  • Pochi PE (1982) Oral retinoids in dermatology. Arch Dermatol 118:57–61

    Google Scholar 

  • Ringenberg QS, Anderson PC (1986) Interferons in the treatment of skin disease. Int J Dermatol 25:273–279

    PubMed  Google Scholar 

  • Rusciani L, Larussa FM, De Simone C, De Sole P,Lippa S, Serri F (1984) Study of the biological function of neutrophils in patients undergoing therapy with the aromatic retinoid Ro 10-9359. In: Saurat JH (ed) Retinoid Symposium. Basel: Karger

    Google Scholar 

  • Shapiro PE, Edelsonn RL (1984) Retinoids and immunology. In: Saurat JH (ed) Retinoid Symposium. Basel: Karger

    Google Scholar 

  • Sillevis-Smitt JH, De Mari F (1984) A serious side effect of etetrinate (Tigason). Clin Exp Dermatol 9:554–556

    PubMed  Google Scholar 

  • Sporn MB (1981) Retinoids: new developments in their mechanism of action as related to control proliferative diseases. In: Orfanos CE, Braun-Falco O, Farber EM, Grupper Ch, Polano MK, Schuppli R (eds) Retinoids, advances in basic research and therapy. Berlin: Springer, p 73

    Google Scholar 

  • Verret JL, Schnitzler L, Avenel M, Smulevici A (1984) Etetrinate and skin cancer prevention. A 6-year follow-up study. In: Saurat JH (ed) Retinoid Symposium. Basel: Karger

    Google Scholar 

  • Ympa SH, Lichti U (1984) Retinoids and carcinogenesis. In: Saurat JH (ed) Retinoid Symposium. Basel: Karger

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Cardamakis, E.K., Kotoulas, LG.B., Dimopoulos, D.P. et al. Comparative study of systemic Interferon alfa-2a with oral isotretinoin and oral isotretinoin alone in the treatment of recurrent condylomata accuminata. Arch Gynecol Obstet 258, 35–41 (1996). https://doi.org/10.1007/BF01370930

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01370930

Key words

Navigation