Abstract
Objectives: We attempted to test the hypothesis that the combination of systemic interferon alfa-2a and oral isotretinoin is more effective than isotretinoin alone in the treatment of recurrent condylomata accuminata.Study design: Fifty seven women with recurrent condylomata accuminata were randomly assigned in two groups. Group A (n = 24) received isotretinoin alone (Roaccutan, Roche) 1 mg/kgr orally daily for 3 months or until a remission was achieved; Group B (n = 33) received Interferon alfa-2a (Roferon-A, Roche) 3 million units subcutaneously three times for 8 weeks plus isotretinoin 1 mg/Kg orally for 3 months or until a remission was achieved.Results: There was no statistically significance in remission rates between the two groups (18/24 vs 28/33,p > 0.1). However the duration of treatment was statistically significantly shorter in Group B (1.9 vs 2.5 months,p < 0.01). Side effects were minimal.
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Cardamakis, E.K., Kotoulas, LG.B., Dimopoulos, D.P. et al. Comparative study of systemic Interferon alfa-2a with oral isotretinoin and oral isotretinoin alone in the treatment of recurrent condylomata accuminata. Arch Gynecol Obstet 258, 35–41 (1996). https://doi.org/10.1007/BF01370930
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DOI: https://doi.org/10.1007/BF01370930