Diagnosis of female genital schistosomiasis by indirect disease markers: determination of eosinophil cationic protein, neopterin and IgA in vaginal fluid and swab eluates
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Cited by (21)
Global Health: Urogenital Schistosomiasis in the Adolescent Girl
2016, Journal of Pediatric and Adolescent GynecologyCitation Excerpt :Given the numerous physical presentations, the variability in examination techniques and availability of diagnostic resources (eg, colposcope), when possible physical exam should not be the sole technique used for diagnosis.5 FGS is often misdiagnosed and since lesions can mimic cancer, women have been subjected to invasive and unnecessary hysterectomies and other procedures.56,57 Table 1 describes available tests for FGS.
Genital schistosomiasis as a cause of female sterility and acute abdomen
2010, Fertility and SterilityCitation Excerpt :Usually in endemic countries, schistosomiasis is treated with a single dose of praziquantel (40 mg/kg body weight). Because this may result in a cure rate of less than 85%, continuing treatment for 3 days is recommended to eradicate the infection (17–19). Data on a cure regimen specific for schistosomiasis of the reproductive tract are still insufficient (20).
Female genital schistosomiasis: Facts and hypotheses
2001, Acta TropicaCitation Excerpt :Various putatively useful marker molecules have been identified, but only a few have been validated (Feldmeier et al., 1995). A promising candidate is eosinophil cationic protein (ECP), a cytotoxic granule protein released by activated eosinophils (Poggensee et al., 1996). Investigations into the usefulness of antigen detection in vaginal fluid are under way.
Assessment of morbidity in Schistosoma haematobium infection: Current methods and future tools
2000, Acta TropicaCitation Excerpt :The median ECP concentration in extracts from vaginal lavage were 6 times higher in women with genital schistosomiasis than in women with urinary scistosomiasis but no egg related genital lesions. However, the concentration of ECP in these women was higher than expected (Poggensee et al. 1996). This may indicate that the diagnosis of FGS was not optimal, which is likely but also that standardization of the procedure for vaginal lavage for measurement of ECP is mandatory since confounding factors like other genital infections and hormonal influences may exist (Witkin et al., 1989; Bélec et al., 1995).
Schistosomiasis of the female genital tract: Public health aspects
1999, Parasitology Today
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Present address: Kilimanjaro Christian Medical Center (KCMC), Moshi, Tanzania.