Cervical human papillomavirus deoxyribonucleic acid persists throughout pregnancy and decreases in the postpartum period☆,☆☆,★
Section snippets
Patients and specimens
Details of the patient populations and specimens collected are contained in our previous report.11 This report contains data derived only from the cohort of pregnant patients. Written informed consent was obtained from all patients in accordance with US Department of Health and Human Services guidelines and with the use of a document approved by the Indiana University–Purdue University at Indianapolis Committee on Protection of Human Subjects. All patients were ≥18 years old and were enrolled
Patient characteristics
As previously reported,11 245 pregnant women were enrolled in the first trimester of pregnancy and complete data were available for 232. Paired results from the first and third trimesters were available for 146 patients, results comparing the first-trimester and postpartum periods were available for 83 patients, and results comparing the third-trimester and postpartum periods were available for 74 patients. The demographic and behavioral characteristics of the patients initially enrolled, those
Comment
The concept that HPV infections are more prominent in pregnancy is one that many clinicians accept on the basis of clinical experience.15 Most of the clinical experience is based on observations of external genital warts, but it is logical that HPV infection at other sites (such as the cervix) would be similarly influenced. Although many published reports attempting to document this phenomenon in a more controlled fashion have been consistent with the anecdotal observation,1, 2, 3, 4, 7, 11, 12
Acknowledgements
We thank Judy Roush, RNC, for her assistance in the collection of specimens and information.
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Cited by (50)
Human papillomavirus infection and spontaneous abortion: A case-control study performed in Mexico
2013, European Journal of Obstetrics and Gynecology and Reproductive BiologyCitation Excerpt :A limitation of this study is the sample size that might have limited the results, but is adequate for this first attempt to describe HPV in spontaneous abortion. In addition, it has been stated that HPV prevalence tends to increase during the trimesters of pregnancy [30,31]. In this respect we should mention that most of the cases were in the first trimester of gestation, and the controls were at term, but despite this bias, HPV prevalence in cases was 24.4% and 15.2% in controls.
Sexually Transmitted Infections in Men and Women
2010, Principles of Gender-Specific MedicineAdeno-associated virus and human papillomavirus types in cervical samples of pregnant and non-pregnant women
2009, European Journal of Obstetrics and Gynecology and Reproductive BiologyCitation Excerpt :These HPV types can be divided between high (16, 18, 26, 33, 35, 40, 59, 64 and 73) and low (6, 11, 32, 61 and 70) risk, without the dominance of a specific type. There are few reports concerning the occurrence of HPV comparing pregnant and non-pregnant women simultaneously [25,26]. Our results showed a greater frequency of HPV during pregnancy, similar to other studies previously reported.
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2008, Journal of Adolescent HealthCimetidine for recurrent respiratory papillomatosis in pregnancy as an alternative adjuvant treatment
2024, European Archives of Oto-Rhino-LaryngologyPrevalence of human papillomavirus and genotype distribution in pregnant and non-pregnant women in china
2021, Risk Management and Healthcare Policy
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Supported by grant AI31494 (Project 4) from the National Institute of Allergy and Infectious Diseases.
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Reprint requests: Kenneth H. Fife, MD, PhD, 545 Barnhill Dr, Emerson Hall 435, Indianapolis, IN 46202-5124.
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