Elsevier

Human Pathology

Volume 28, Issue 8, August 1997, Pages 899-904
Human Pathology

Original contribution
Human papillomavirus findings in relation to cervical intraepithelial neoplasia grade: A study on 476 stockholm women, using pcr for detection and typing of HPV

https://doi.org/10.1016/S0046-8177(97)90004-6Get rights and content

Abstract

Among human papillomavirus (HPV) types found in humans, there is a strong association between HPV 16, 18, 31, and 33, and cervical cancer. The relationship between various grades of dysplasia and HPV type is less clear. To elucidate this point, the authors tested 476 cytological and histological samples from cervix with polymerase chain reaction (PCR) for HPV using consensus primer My 09–11 and type-specific primers. All cases were divided into groups on the basis of cytology: “normal cases” (ie, women with other disease than cervical intraepithelial neoplasia [Cin]), and CIN I, II, and III. Out of the “normal cases,” in which women with a previous history of condyloma and dysplasia were included, 69% had HPV with type 6 as the most common one. Of all CIN I cases, 71% were HPV positive, and HPV type 6 and 16 were equally common. In CIN II cases, HPV 16 was the most common type, whereas HPV 6 accounted for only 7.5% of cases in this group as single virus type. HPV 16 was also the most common type in the CIN III group, followed by type 33. Double and even multiple infections occurred in all groups.

References (45)

  • V Kataja et al.

    Prospective follow-up of cervical HPV infections: Life table analysis of histopathological, cytological and colposcopic data

    Eur J Epidemiol

    (1989)
  • K Syrjänen et al.

    Natural history of cervical human papillomavirus lesions does not substantiate the biologic relevance of the Bethesda system

    Obstet Gynecol

    (1992)
  • H zur Hausen

    Papillomaviruses in anogenital cancer as a model to understand the role of viruses in human cancers

    Cancer Res

    (1989)
  • H zur Hansen

    Molecular pathogenesis of cancer of the cervix and its causation by specific human papillomavirus types

    Curr Top Microbiol Immunol

    (1994)
  • D Solomon

    Screening for cervical cancer: Prospects for the future

    J Natl Cancer Inst

    (1993)
  • V Mayelo et al.

    Cell abnormalities associated with human papillomavirus-induced squamous intraepithelial cervical lesions: Multivariate data analysis

    Am J Clin Pathol

    (1994)
  • NB Kiviat et al.

    Specific human papillomavirus types as the causal agents of most cervical intraepithelial neoplasia: Implications for current views and treatment

    J Natl Cancer Inst

    (1993)
  • MH Schiffman

    Epidemiology of cervical human papillomavirus infections

    Curr Top Microbiol Immunol

    (1994)
  • C Bergeron et al.

    Human papillomaviruses associated with cervical intraepithelial neoplasia

    Am J Surg Pathol

    (1992)
  • KN Gaarenstroom et al.

    Human papillomavirus DNA and genotypes: Prognostic factors for progression of cervical intraepithelial neoplasia

    Int J Gynecol Cancer

    (1994)
  • CS Herrington et al.

    Human papillomavirus status in the prediction of high-grade cervical intraepithelial neoplasia in patients with persistent low-grade cervical cytological abnormalities

    Br J Cancer

    (1995)
  • MPM Burger et al.

    Predictive value of human papillomavirus type for histological diagnosis of women with cervical cytological abnormalities

    Br Med J

    (1995)
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