Elsevier

The Lancet

Volume 354, Issue 9185, 2 October 1999, Pages 1176-1177
The Lancet

Research Letters
Intoxication due to negative canrenone interference in digoxin drug monitoring

https://doi.org/10.1016/S0140-6736(99)03818-0Get rights and content

Summary

Canrenone and spironolactone caused falsely low readings in a common assay for digoxin (AxSym MEIA) due to negative cross-reactivity. Misleading subtarget concentrations were repeatedly reported, and falsely guided drug dosing resulted in a case of digoxin intoxication.

References (5)

  • SA Jortani et al.

    Digoxin and its related endogenous factors

    Crit Rev Clin Lab Sci

    (1997)
  • RA Pleasants et al.

    Reassessment of cross-reactivity of spironolactone metabolites with four digoxin immunoassays

    Ther Drug Monit

    (1989)
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