Contact urticaria and allergic contact dermatitis to benzocaine gel

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A 39-year-old man developed edema and vesiculation of the oral mucosa following the application of benzocaine (Hurricaine) gel. Open testing demonstrated an immediate urticarial reaction. Closed patch tests were positive after 48 hours. The contact dermatitis was consistent with a delayed-type hypersensitivity. It appears, however, that a nonimmunologic mechanism caused the contact urticaria since passive transfer was negative.

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Cited by (16)

  • Immunologic Contact Urticaria

    2014, Immunology and Allergy Clinics of North America
    Citation Excerpt :

    Topical local anesthetics also have the ability to cause ICU. Ryan and colleagues40 (1980) reported on mucosal contact urticaria to benzocaine, whereas Waton and colleagues41 (2004) reported on contact urticaria to lidocaine from the use of a local anesthetic cream used for venesection. It is claimed that most cases of contact urticaria to local anesthetic agents are nonimmunologic.42

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  • Occupational contact urticaria

    1992, Clinics in Dermatology
  • The contact urticaria syndrome

    1985, Dermatologic Clinics
  • The contact urticaria syndrome—an updated review

    1981, Journal of the American Academy of Dermatology
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From the Department of Dermatology, Wilford Hall USAF Medical Center

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