Abstract
HERPES simplex virus type 1 (HSV-1) Us11 protein, a true late gene product packaged within the virion, is delivered into cells after infection, exhibits a nucleocytoplasmic localization at early times, and later accumulates in the nucleoli1–5. This RNA-binding basic phosphoprotein, capable of oligomerization, is supposed to be involved in post-transcriptional regulation of gene expression after HSV-1 infection6,7. Expression of human T-cell leukaemia/ lymphoma virus type-I (HTLV-I) and of human immunodeficiency virus type 1 (HIV-1) is post-transcriptionally regulated by Rex and Rev, respectively8. These proteins are required for the cytoplasmic expression of unspliced gag-pol and singly spliced env transcripts9,10. Here we show that HSV-1 Us11 protein is able to bind Rex- and Rev-responsive elements and to transactivate envelope retroviral glycoprotein expression.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 51 print issues and online access
$199.00 per year
only $3.90 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Massé, T., Garcin, D., Jacquemont, B. & Madjar, J.-J. Molec gen. Genet. 220, 377–388 (1990).
Roller, R. J. & Roizman, B. J. Virol. 66, 3624–3632 (1992).
MacLean, C. A., Rixon, F. J. & Marsden, H. S. J. gen. Virol 68, 1921–1937 (1987).
Puvion-Dutilleul, F. Eur. J. Cell Biol. 43, 487–498 (1987).
Johnson, P. A., MacLean, C., Marsden, H. S., Dalziel, R. G. & Everett, R. D. J. gen. Virol. 67, 871–883 (1986).
Roller, R. J. & Roizman, B. J. Virol. 65, 5873–5879 (1991).
Diaz, J.-J. et al. J. gen. Virol. 74, 397–406 (1993).
Cullen, B. R. Microbiol. Rev. 56, 375–394 (1992).
Malim, M. H., Hauber, J., Le, S.-Y., Maizel, J. V. & Cullen, B. R. Nature 338, 254–257 (1989).
Ballaun, C. et al. J. Virol. 65, 4408–4413 (1991).
Inoue, J.-I., Itoh, M., Akizawa, T., Toyoshima, H. & Yoshida, M., Oncogene 6, 1753–1757 (1991).
Malim, M. H., Hauber, J., Fenrick, R. & Cullen, B. R. Nature 335, 181–183 (1988).
Rimsky, L., Duc Dodon, M., Dixon, E. P. & Greene, W. C. Nature 341, 453–456 (1989).
Roller, R. J. & Roizman, B. J. Virol. 64, 3463–3470 (1990).
Malim, M. H. & Cullen, B. R. Cell, 65, 241–248 (1991).
Bogerd, H. P., Tiley, L. & Cullen, B. R. J. Virol. 66, 7572–7575 (1992).
Bogerd, H. P., Huckaby, G. L., Ahmed, Y. F., Hanly, S. M. & Greene, W. C. Proc. natn. Acad. Sci. U.S.A. 88, 5704–5708 (1991).
Rixon, F. J. & McGeoch, D. J. Nucleic Acids Res. 12, 2473–2487 (1984).
Cullen, B. R. Cell 46, 973–982 (1986).
Rimsky, L. et al. Nature 335, 738–740 (1988).
Chen, C. & Okayama, H. Molec. cell. Biol. 7, 2745–2752 (1987).
Nerenberg, M., Hinrichs, S. H., Reynolds, R. K., Khoury, G. & Jay, G. Science 237, 1324–1329 (1987).
Tanaka, Y., Zeng, L., Shitaki, H., Shida, H. & Tozawa, H. J. Immun. 147, 354–360 (1991).
Palker, T. J. et al. J. Virol. 66, 5879–5889 (1992).
Charneau, P., Alizon, M. & Clavel, F. J. Virol. 66, 2814–2820 (1992).
Emerman, M., Vazeux, R. & Peden, K. Cell 57, 1155–1165 (1989).
Hanahan, D. J. molec. Biol. 166, 557–580 (1983).
Tan, W. & Schwartz, S. J. Virol. 69, 2932–2945 (1995).
Stallcup, M. R. & Washington, L. D. J. biol. Chem. 258, 2802–2807 (1993).
Nakajima-Iijima, S., Hamada, H., Reddy, P. & Kakunaga, T. Proc. natn. Acad. Sci. U.S.A. 82, 6133–6137 (1985).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Diaz, JJ., Due Dodon, M., Schaerer-Uthurralt, N. et al. Post-transcriptional transactivation of human retroviral envelope glycoprotein expression by herpes simplex virus Us11 protein. Nature 379, 273–277 (1996). https://doi.org/10.1038/379273a0
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1038/379273a0
This article is cited by
-
Prevalence of herpes simplex virus 2 among MSM in Mainland China: a systematic review and meta-synthesis
AIDS Research and Therapy (2022)
-
Expression, purification of herpes simplex virus type 1 US11 Protein, and production of US11 polyclonal antibody
Virology Journal (2011)
-
Update in HIV Medicine for the Generalist
Journal of General Internal Medicine (2011)
-
Can herpes simplex virus type 2 suppression slow HIV disease progression: a study protocol for the VALacyclovir In Delaying Antiretroviral Treatment Entry (VALIDATE) trial
Trials (2010)
-
New insights on interactions between HIV-1 and HSV-2
Current Infectious Disease Reports (2009)
Comments
By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate.