Abstract
Canrenone and spironolactone caused falsely low readings in a common assay for digoxin (AxSym MEIA) due to negative cross-reactivity. Misleading subtarget concentrations were repeatedly reported, and falsely guided drug dosing resulted in a case of digoxin intoxication.
Publication types
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Case Reports
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Letter
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Canrenone / blood*
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Digoxin / blood*
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Digoxin / poisoning*
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Drug Interactions
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Drug Monitoring / methods*
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Enzyme Multiplied Immunoassay Technique
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Fatal Outcome
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Humans
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Male
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Medication Errors*
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Multiple Organ Failure / etiology
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Sepsis / complications
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Spironolactone / blood*
Substances
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Spironolactone
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Digoxin
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Canrenone