Abstract
Available data demonstrate an increase in the transcription of high-risk papillomaviruses by the 16alpha-hydroxylation of estrogens, which is in line with the epidemiologic data showing an increased cervical carcinogenesis risk for long-term contraceptive-using, HPV-infected women. No evidence exists for an increase in HPV-negative contraceptive users.
Copyright 2002 Wiley-Liss, Inc.
MeSH terms
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Contraceptives, Oral, Hormonal*
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Estrogens / metabolism
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Female
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Humans
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Hydroxylation
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Papillomaviridae / physiology*
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Papillomavirus Infections / virology*
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Tumor Virus Infections / virology*
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Uterine Cervical Dysplasia / epidemiology
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Uterine Cervical Dysplasia / virology*
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Uterine Cervical Neoplasms / epidemiology
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Uterine Cervical Neoplasms / virology*
Substances
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Contraceptives, Oral, Hormonal
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Estrogens