The protean ocular manifestations of patients with the acquired immunodeficiency syndrome (AIDS) have been well documented both clinically and histopathologically. Since 1978, many case reports have emphasized the opportunistic ocular infections in patients with AIDS. We report the clinicopathologic findings in a patient with AIDS who demonstrated focal necrosis of the ciliary processes and cerebellum due to cytomegalovirus (CMV). The former explained the clinical manifestations of uveitis and the latter masqueraded as drug toxicity.