Comparison of tinidazole given as a single dose and on 2 consecutive days for the treatment of nonspecific bacterial vaginosis

J Ekgren; B K Norling; M Degre; T Midtvedt

doi:10.1159/000293712

Comparison of tinidazole given as a single dose and on 2 consecutive days for the treatment of nonspecific bacterial vaginosis

Gynecol Obstet Invest. 1988;26(4):313-7. doi: 10.1159/000293712.

Authors

J Ekgren¹, B K Norling, M Degre, T Midtvedt

Affiliation

¹ Møllergaten spesiallegesenter, Oslo, Norway.

PMID: 3068098
DOI: 10.1159/000293712

Abstract

Nonspecific bacterial vaginosis, defined as the presence of clue cells, was treated in a randomized, double-blind study with (1) tinidazole 2 g as a single dose (82 patients), (2) tinidazole 2 g on 2 consecutive days (84 patients), and (3) with placebo (81 patients). The cure rates, both clue cells and Gardnerella vaginalis absent, were 51, 74 and 4%, respectively. A closer clinical and microbiological evaluation showed the 2-day regimen to be superior.

Publication types

Clinical Trial
Comparative Study
Randomized Controlled Trial

MeSH terms

Adult
Clinical Trials as Topic
Double-Blind Method
Drug Administration Schedule
Female
Gardnerella vaginalis / drug effects
Haemophilus Infections / drug therapy*
Humans
Nitroimidazoles / administration & dosage*
Random Allocation
Tinidazole / administration & dosage*
Tinidazole / therapeutic use
Vaginal Diseases / drug therapy*

Substances

Nitroimidazoles
Tinidazole