Abstract
Two men who acquired acute gonococcal urethritis in The Netherlands and who were treated with cefuroxime (1.5 g given intramuscularly) failed to respond to this therapy. Pre- and post-treatment isolates of Neisseria gonorrhoeae from these patients had MICs of 0.5 and 1.0 microgram of cefuroxime/ml.
MeSH terms
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Adult
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Cefuroxime / therapeutic use*
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Cephalosporins / therapeutic use*
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Drug Resistance, Microbial
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Gonorrhea / drug therapy*
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Gonorrhea / microbiology
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Humans
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Male
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Neisseria gonorrhoeae / drug effects
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Neisseria gonorrhoeae / enzymology
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Penicillinase / biosynthesis
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Urethritis / drug therapy*
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Urethritis / microbiology
Substances
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Cephalosporins
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Penicillinase
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Cefuroxime