Abstract
We describe an immunocompetent 12-year-old boy with chronic EBV infection and lymphoid interstitial pneumonitis. Lymph node biopsies showed effacement of the architecture with polymorphic cellular infiltrates, consisting predominantly of T cells and natural killer cells. No clonal rearrangement of TCR or immunoglobulin genes was seen. DNA was extracted from hilar lymph nodes; sequencing of the carboxy terminal region of the latent membrane protein 1 (LMP-1) oncogene revealed a 69 base-pair deletion and four point mutations. Immunosuppressive treatment with prednisone and cyclosporine reversed the lymphadenopathy.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Base Composition
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Base Sequence
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Child
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Cyclosporine / therapeutic use
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DNA Primers / genetics
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Electrophoresis, Agar Gel
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Gene Deletion*
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Herpesviridae Infections / drug therapy
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Herpesviridae Infections / genetics*
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Herpesviridae Infections / pathology
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Herpesvirus 4, Human / immunology*
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Humans
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Lung Diseases, Interstitial / drug therapy
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Lung Diseases, Interstitial / genetics
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Lung Diseases, Interstitial / pathology
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Lymph Nodes / pathology
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Male
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Molecular Sequence Data
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Point Mutation
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Polymerase Chain Reaction
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Prednisolone / therapeutic use
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Tumor Virus Infections / drug therapy
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Tumor Virus Infections / genetics*
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Tumor Virus Infections / pathology
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Viral Matrix Proteins / genetics*
Substances
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DNA Primers
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EBV-associated membrane antigen, Epstein-Barr virus
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Viral Matrix Proteins
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Cyclosporine
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Prednisolone