Background Early antiretroviral therapy (ART) initiation (ie, within 3 months of infection)
limits establishment of the HIV reservoir. However, the effect of early ART initiation on the …

Abstract The Sabes Study evaluated a treatment-as-prevention intervention among
cisgender men who have sex with men and transgender women in Lima, Peru—populations …

The validity of various indicators of response distortion on the Personality Assessment
Inventory–Adolescent (PAI–A; Morey, 2007a) and its potential usefulness to detect …

The introduction of SARS-CoV-2 variants of concern (VOCs) in Brazil has been associated
with major impacts on the epidemiological and public health scenario. In this study, 291,571 …

Background In addition to demonstrated public health benefits on reducing transmission, it
remains unclear how early antiretroviral therapy (ART) must be started after acquisition of …

Abstract Background Expedited Partner Therapy (EPT) has been shown to improve
treatment outcomes among heterosexual partners of individuals with curable sexually …

Wnt proteins contain palmitoleic acid, an unusual lipid modification. Production of an active
Wnt signal requires the acyltransferase Porcupine and depends on the attachment of …

Abstract Inhibition of Sonic hedgehog (Shh) signaling is of great clinical interest. Here we
exploit Hedgehog acyltransferase (Hhat)-mediated Shh palmitoylation, a modification critical …

β-Catenin is a key component of the Wnt signaling pathway that functions as a
transcriptional co-activator of Wnt target genes. Upon UV-induced DNA damage, β-catenin …

Wnts comprise a family of lipid-modified, secreted signaling proteins that control
embryogenesis, as well as tissue homeostasis in adults. Post-translational attachment of …