Sickle cell disease is a common and life-threatening haematological disorder that affects
millions of people worldwide. Abnormal sickle-shaped erythrocytes disrupt blood flow in …

OBJECTIVES: Despite the widespread use of neonatal screening programmes for sickle cell
disease in Western regions, few studies have focused on the special healthcare needs in …

Background Hydroxyurea is an effective treatment for sickle cell anemia, but few studies
have been conducted in sub-Saharan Africa, where the burden is greatest. Coexisting …

Background: Despite the high prevalence of sickle cell disease in Africa, a neonatal
screening programme is available in only a few countries in the sub-Saharan region. Aim …

Importance Little is known about COVID-19 outcomes among children and adolescents in
sub-Saharan Africa, where preexisting comorbidities are prevalent. Objective To assess the …

Globally, there are prevailing knowledge gaps in the epidemiology, clinical manifestations,
and outcomes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection …

Background Sickle cell anemia (SCA) is an inherited hematological disorder that causes a
large but neglected global health burden, particularly in Africa. Hydroxyurea represents the …

In an effort to explore new knowledge and to develop meaningful collaborations for
improving child health, the First Pan African Workshop on Newborn Screening was …

Abstract Realizing Effectiveness Across Continents with Hydroxyurea (REACH,
NCT01966731) provides hydroxyurea at maximum tolerated dose (MTD) for children with …

For more than two years after the emergence of COVID-19 (Coronavirus Disease-2019),
significant regional differences in morbidity persist. These differences clearly show lower …