Almost half of all enzymes must associate with a particular metal to function. An ambition is
to understand why each metal–protein partnership arose and how it is maintained. Metal …

Abstract Information on age-and sex-specific prevalence of herpes simplex virus (HSV)
types 2 and 1 infections is essential to optimize genital herpes control strategies, which …

Protein metal-coordination sites are richly varied and exquisitely attuned to their inorganic
partners, yet many metalloproteins still select the wrong metals when presented with …

Iron deficiency afflicts more than three billion people worldwide, and plants are the principal
source of iron in most diets. Low availability of iron often limits plant growth because iron …

The current state of knowledge on how copper metallochaperones support the maturation of
cuproproteins is reviewed. Copper is needed within mitochondria to supply the CuA and …

Metals are needed by at least one-quarter of all proteins,. Although metallochaperones,,,,,
insert the correct metal into some proteins, they have not been found for the vast majority …

It has been hypothesized that plants contain respiratory burst oxidases which, upon
activation, oxidize NADPH and generate extracellular superoxide, O2°−. These proteins are …

Murine models of inflammatory bowel disease (IBD) are useful tools for the study of the
pathogenesis and regulation of intestinal inflammation. Colitis can be induced in immune …

The metal binding preferences of most metalloproteins do not match their metal
requirements. Thus, metallation of an estimated 30% of metalloenzymes is aided by metal …

Objective: To identify factors that could explain differences in rate of spread of HIV between
different regions in sub-Saharan Africa. Design: Cross-sectional study. Methods: The study …