User profiles for "author:Douglas Taylor"

Douglas Taylor

University of Virginia
Verified email at virginia.edu
Cited by 7766

Methods of isolating extracellular vesicles impact down-stream analyses of their cargoes

DD Taylor, S Shah - Methods, 2015 - Elsevier
Viable tumor cells actively release vesicles into the peripheral circulation and other biologic
fluids, which exhibit proteins and RNAs characteristic of that cell. Our group demonstrated …

Exosomes/microvesicles: mediators of cancer-associated immunosuppressive microenvironments

DD Taylor, C Gercel-Taylor - Seminars in immunopathology, 2011 - Springer
Cancer cells, both in vivo and in vitro, have been demonstrated to release membranous
structures, defined as microvesicles or exosomes, consisting of an array of macromolecules …

History, chance and adaptation during biological invasion: separating stochastic phenotypic evolution from response to selection

SR Keller, DR Taylor - Ecology letters, 2008 - Wiley Online Library
Introduced species often exhibit changes in genetic variation, population structure, selection
regime and phenotypic traits as they colonize and expand into new ranges. For these …

Retracted: microRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer

DD Taylor, C Gercel-Taylor - 2008 - Elsevier
OBJECTIVES: Most ovarian cancer patients are diagnosed at an advanced stage (67%) and
prospects for significant improvement in survival reside in early diagnosis. While expression …

Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women

Q Abdool Karim, SS Abdool Karim, JA Frohlich… - science, 2010 - science.org
The Centre for the AIDS Program of Research in South Africa (CAPRISA) 004 trial assessed
the effectiveness and safety of a 1% vaginal gel formulation of tenofovir, a nucleotide …

Exosomal microRNA: a diagnostic marker for lung cancer

G Rabinowits, C Gerçel-Taylor, JM Day, DD Taylor… - Clinical lung cancer, 2009 - Elsevier
Purpose To date, there is no screening test for lung cancer shown to affect overall mortality.
MicroRNAs (miRNAs) are a class of small noncoding RNA genes found to be abnormally …

[HTML][HTML] Preexposure prophylaxis for HIV infection among African women

L Van Damme, A Corneli, K Ahmed… - … England Journal of …, 2012 - Mass Medical Soc
Background Preexposure prophylaxis with antiretroviral drugs has been effective in the
prevention of human immunodeficiency virus (HIV) infection in some trials but not in others …

Defective angiogenesis in mice lacking endoglin

DY Li, LK Sorensen, BS Brooke, LD Urness, EC Davis… - Science, 1999 - science.org
Endoglin is a transforming growth factor–β (TGF-β) binding protein expressed on the surface
of endothelial cells. Loss-of-function mutations in the human endoglin gene ENG cause …

[HTML][HTML] Vesiclepedia: a compendium for extracellular vesicles with continuous community annotation

H Kalra, RJ Simpson, H Ji, E Aikawa, P Altevogt… - PLoS …, 2012 - journals.plos.org
Extracellular vesicles (EVs) are membraneous vesicles released by a variety of cells into
their microenvironment. Recent studies have elucidated the role of EVs in intercellular …

[HTML][HTML] Micro-Raman spectroscopy detects individual neoplastic and normal hematopoietic cells

JW Chan, DS Taylor, T Zwerdling, SM Lane, K Ihara… - Biophysical journal, 2006 - cell.com
Current methods for identifying neoplastic cells and discerning them from their normal
counterparts are often nonspecific, slow, biologically perturbing, or a combination thereof …