[HTML][HTML] PAI-1: an integrator of cell signaling and migration

RP Czekay, CE Wilkins-Port, SP Higgins… - International journal of …, 2011 - hindawi.com
Cellular migration, over simple surfaces or through complex stromal barriers, requires
coordination between detachment/re-adhesion cycles, involving structural components of …

TGF-β1→ SMAD/p53/USF2→ PAI-1 transcriptional axis in ureteral obstruction-induced renal fibrosis

R Samarakoon, JM Overstreet, SP Higgins… - Cell and tissue …, 2012 - Springer
Chronic kidney disease constitutes an increasing medical burden affecting 26 million people
in the United States alone. Diabetes, hypertension, ischemia, acute injury, and urological …

TGF-β1/p53 signaling in renal fibrogenesis

SP Higgins, Y Tang, CE Higgins, B Mian, W Zhang… - Cellular signalling, 2018 - Elsevier
Fibrotic disorders of the renal, pulmonary, cardiac, and hepatic systems are associated with
significant morbidity and mortality. Effective therapies to prevent or curtail the advancement …

TGF-β1-induced plasminogen activator inhibitor-1 expression in vascular smooth muscle cells requires pp60c-src/EGFRY845 and Rho/ROCK signaling

R Samarakoon, SP Higgins, CE Higgins… - Journal of molecular and …, 2008 - Elsevier
TGF-β1 and its target gene encoding plasminogen activator inhibitor-1 (PAI-1) are major
causative factors in the pathology of tissue fibrosis and vascular disease. The increasing …

SERPINE1: a molecular switch in the proliferation-migration dichotomy in wound-“activated” keratinocytes

TM Simone, CE Higgins, RP Czekay, BK Law… - Advances in wound …, 2014 - liebertpub.com
Significance: A highly interactive serine protease/plasmin/matrix metalloproteinase axis
regulates stromal remodeling in the wound microenvironment. Current findings highlight the …

Syphilis: old problem, new strategy

L Doherty, KA Fenton, J Jones, TC Paine, SP Higgins… - Bmj, 2002 - bmj.com
Infectious syphilis is a disease of considerable public health importance, with overwhelming
health effects if it is not treated. These include cardiovascular and neurological disease and …

Primary syphilis

K Eccleston, L Collins… - International journal of …, 2008 - journals.sagepub.com
Primary syphilis - Kathryn Eccleston, Lisa Collins, Stephen P Higgins, 2008 Skip to main content
Intended for healthcare professionals SAGE Journals Home Search this journal Search all …

[HTML][HTML] Redox-Induced Src Kinase and Caveolin-1 Signaling in TGF-β1-Initiated SMAD2/3 Activation and PAI-1 Expression

R Samarakoon, SS Chitnis, SP Higgins, CE Higgins… - PloS one, 2011 - journals.plos.org
Background Plasminogen activator inhibitor-1 (PAI-1), a major regulator of the plasmin-
based pericellular proteolytic cascade, is significantly increased in human arterial plaques …

SERPINE1 (PAI-1) is deposited into keratinocyte migration “trails” and required for optimal monolayer wound repair

KM Providence, SP Higgins, A Mullen, A Battista… - Archives of …, 2008 - Springer
Cutaneous tissue injury, both in vivo and in vitro, initiates activation of a “wound repair”
transcriptional program. One such highly induced gene encodes plasminogen activator …

[HTML][HTML] The TGF-β1/p53/PAI-1 signaling axis in vascular senescence: Role of caveolin-1

R Samarakoon, SP Higgins, CE Higgins, PJ Higgins - Biomolecules, 2019 - mdpi.com
Stress-induced premature cellular senescence is a significant factor in the onset of age-
dependent disease in the cardiovascular system. Plasminogen activator inhibitor-1 (PAI-1) …