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Evaluation of near patient testing for Chlamydia trachomatis in a pregnancy termination service
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  1. Jennifer Hopwood, MB ChB, D(Obst)RCOG, Dip Ven, MFFP, Senior Clinical Medical Officer1,
  2. Harry Mallinson, PhD, Principal Microbiologist2 and
  3. Toni Gleave, RGN BA (Hons) MSc, Community Health Adviser3
  1. Wirral and West Cheshire Community NHS Trust, Co-ordinator Wirral DH Chlamydia Pilot Scheme, St Catherine's Hospital, Wirral, UK
  2. University Hospital, Aintree, UK
  3. St Catherine's Hospital, Wirral, UK
  1. Correspondence Dr JJ Hopwood, Chlamydia Pilot Office, Evidence Based Practice Centre, St Catherine's Hospital, Birkenhead, CH44 0LQ.

Abstract

Aim To identify and evaluate advantages and disadvantages of a near patient test (NPT) for Chlamydia trachomatis, using Clearview Chlamydia MF (Unipath Ltd) in a British Pregnancy Advisory Service (BPAS) clinic.

Method The improved Clearview Chlamydia MF test was used to test endocervical swabs from 400 women attending BPAS clinic for termination of pregnancy. The results were compared with Ligase Chain Reaction (LCR), using Polymerase Chain Reaction (PCR) as the arbiter.

Results Twenty-seven women tested positive by Clearview Chlamydia MF (24 confirmed by LCR) and 32 by LCR.

Comment NPT has potential advantages in specific situations where a quick result is required for optimal management of those testing positive. However, the current technology available for detection of Chlamydial infection results in time constraints, which limited its benefits in this study, where there was a high throughput of clients.

A significant number of cases were missed by Clearview Chlamydia MF, though the sensitivity found is within the ranges reported for various enzyme immunoassays (EIA) - currently the most commonly used testing method.

The study confirmed the high positivity in those attending for termination, especially in under 25-year-olds.

https://doi.org/10.1783/147118901101195515

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