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Circulating immune complexes in syphilitic nephropathy. A case report.
  1. J Sølling,
  2. K Sølling,
  3. K U Jacobsen,
  4. S Olsen,
  5. E From


    A case of transient nephrotic syndrome caused by secondary syphilis is described. A renal biopsy was performed revealing subepithelial hump-like electron-dense deposits and fusion of epithelial foot-processes. Complement C1q-binding-activity and anticomplementarity were demonstrated in the blood, indicating the presence of circulating immune complexes. This strongly suggests that circulating immune complexes are significant in the immunopathogenesis of syphilitic nephropathy.

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