In a double-blind study amoxycillin 3 g or ampicillin 3 g plus probenecid 1 g were randomly administered as a single oral dose to 160 men with uncomplicated gonococcal urethritis. The cure rate for each drug group was 98.6%. Tolerance to oral medication was good and no evidence of allergy or toxicity to either drug was shown. No case of post-gonococcal urethritis was observed over a 14-day follow-up period. Thus, both drug regimens proved very effective in treating uncomplicated gonococcal urethritis in men.
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