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Managing trichomonal vaginitis refractory to conventional treatment with metronidazole.
  1. I H Ahmed-Jushuf,
  2. A E Murray,
  3. J McKeown
  1. Department of Genitourinary Medicine, Royal Hospital, Liverpool.


    Three patients with vulvovaginitis caused by Trichomonas vaginalis, which was refractory to conventional treatment with metronidazole are described. The T vaginalis strain isolated from one patient was resistant to metronidazole (minimum inhibitory concentration (MIC) more than 100 mg/l) under aerobic conditions, although under anaerobic conditions it was as susceptible as a normal reference strain. The effect of the concomitant use of other medication and the influence of other vaginal pathogens on the efficacy of metronidazole are highlighted.

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