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HSV-2 specific seroprevalence among various populations in Rome, Italy
  1. B Suligoi1,
  2. M Cusan2,
  3. P Santopadre3,
  4. G Palù4,
  5. S Catania5,
  6. G Girelli6,
  7. S Pala7,
  8. V Vullo8,
  9. The Italian Herpesmanagement Forum*
  1. 1Reparto AIDS e MST, Istituto Superiore di Sanità, Rome, Italy
  2. 2Istituto di Microbiologia, University of Padua, Padua, Italy
  3. 3Clinica Malattie Infettive, “La Sapienza” University, Rome, Italy
  4. 4Istituto di Microbiologia, University of Padua, Padua, Italy
  5. 5Clinica Malattie Infettive, “La Sapienza” University, Rome, Italy
  6. 6Dipartimento di biotecnologie cellulari ed ematologia, “La Sapienza” University, Rome, Italy
  7. 7Clinica Dermatologica, “La Sapienza” University, Rome, Italy
  8. 8Clinica Malattie Infettive, “La Sapienza” University, Rome, Italy
  1. Barbara Suligoi, National AIDS and STD Unit, Istituto Superiore di Sanità, V le Regina Elena 299, 00161 Rome, Italy suligoi{at}

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Demographic data

We conducted a cross sectional seroprevalence study on anonymous banked blood samples taken from adults for various reasons, between January and September 1998 at “La Sapienza” University Hospital, Rome, Italy. Blood samples were available for the following four groups of individuals:

  1. military recruits, from various Italian regions, undergoing routine medical examination for enrolment in the military service

  2. people attending an outpatient facility for either vaccination against viral hepatitis B or post-exposure prophylaxis

  3. blood donors

  4. pregnant women undergoing routine serological controls.



All samples were tested with a commercially available kit approved by the US Food and Drug Administration: the herpes simplex virus (HSV) type 2 specific gG ELISA test manufactured by Meridian Diagnostics Inc (Cincinnati, OH, USA). The sensitivity and specificity of the test are 98% and 97%, respectively.1


To test …

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  • * The Italian Herpes Management Forum (consisting of F Boselli, R Caputo, M Cusini, S Delia, G Gentile, P Martino, G Palù, B Suligoi, A Volpi, V Vullo) designed the study and were involved in discussion of the results.