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Cheilitis in association with indinavir
  1. P A Fox,
  2. D A Hawkins,
  3. R C D Staughton
  1. Departments of HIV medicine and Dermatology, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH
  1. Dr Fox

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Editor,—There is increasing speculation that indinavir may cause side effects which have been previously associated with high concentrations of retinoids. In the presence of all-trans-retinoic acid (ATRA), indinavir, but not other protease inhibitors (PIs), alters stem cell differentiation in vitro, not seen in the presence of ATRA alone.1 Alopecia and cheilitis are two side effects associated with both retinoids and the protease inhibitor indinavir (but not …

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