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Detection of 14-3-3 brain protein in cerebrospinal fluid of HIV infected patients
  1. R F Miller,
  2. A J E Green,
  3. G Giovannoni,
  4. E J Thompson
  1. Department of Sexually Transmitted Diseases, Royal Free and University College Medical School, Mortimer Market Centre, Mortimer Market, Off Capper Street, London WC1E 6AU, UK
  2. Department of Neuroimmunology, Institute of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG
  1. Dr Miller

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Editor,—The 14-3-3 proteins are a group of highly conserved proteins involved in intracellular signalling. Detection of 14-3-3 brain protein has been described in cerebrospinal fluid (CSF) of patients with transmissible spongiform encephalopathies including both sporadic and variant Creutzfeldt–Jakob disease.1,2 False positive results have been reported in conditions producing (sub)acute neuronal destruction, including herpes simplex encephalitis, ischaemic stroke, multi-infarct dementia, and paraneoplastic syndromes.1–3 We postulated that 14-3-3 brain protein may be detected in CSF from patients with HIV associated dementia complex (HADC) as this condition is characterised neuropathologically by a giant cell …

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