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No association of anti-Chlamydia trachomatis antibodies and severity of cervical neoplasia
  1. N Reesink-Peters1,
  2. J M Ossewaarde2,
  3. A G J Van Der Zee3,
  4. W G V Quint4,
  5. M P M Burger1,
  6. A H Adriaanse1
  1. 1Department of Obstetrics and Gynaecology, Academic Medical Centre, University of Amsterdam, Netherlands
  2. 2National Institute of Public Health and the Environment
  3. 3Department of Obstetrics and Gynaecology, University Hospital Groningen
  4. 4Delft Diagnostic Laboratory, Delft
  1. A H Adriaanse, MD, PhD, Division of Obstetrics and Gynaecology, Academic Medical Centre, PO Box 22660, 1100 DD Amsterdam, Netherlands a.h.adriaanse{at}amc.uva.nl

Abstract

Objective: To explore whether the presence of Chlamydia trachomatis antibodies is associated with the severity of neoplastic lesions in women with cervical dyskaryosis.

Methods: In a cross sectional study in two groups of women referred for an abnormal Papanicolaou smear (group A: 296, group B: 331 women) blood samples were analysed for antichlamydial antibodies by enzyme immunoassay. Cervical neoplasia was graded histologically.

Results: In group A no association was found between increasing grade of CIN and the presence of antichlamydial antibodies. The proportion (93%) of women with antichlamydial antibodies was higher in 14 women with (micro)invasive carcinoma than in women with CIN (35%). As the high prevalence of antichlamydial antibodies in women with cervical carcinoma is not consistent with prevalences reported in recent literature, we analysed a second group of women in which indeed the high prevalence was not confirmed

Conclusion: Our results suggest that the presence of circulating antichlamydial antibodies is not associated with the severity of neoplastic lesions and it seems unlikely that C trachomatis has a role in the progression of cervical neoplasia.

  • cervical neoplasia
  • Chlamydia trachomatis

https://doi.org/10.1136/sti.77.2.101

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