Recently, the quinolone class of antibiotics has been used successfully in a few patients with granuloma inguinale.^1–3 We report a case of chronic granuloma inguinale, failing repeated antibiotic treatment over 15 years, which responded to a 2 month course of trovofloxacin.

A 33 year old white woman developed granuloma inguinale involving the vulva, left labia, and vaginal canal since about 1982. Over the years, she was treated with doxycycline, ampicillin, erythromycin, trimethoprim/sulfamethoxazole, intramuscular injection of ceftriaxone, and then intravenous gentamicin or chloramphenicol for several weeks. The …