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Combined topical flucytosine and amphotericin B for refractory vaginal Candida glabrata infections
  1. D J White1,
  2. A R Habib1,
  3. A Vanthuyne1,
  4. S Langford2,
  5. M Symonds3
  1. 1Department of Sexual Medicine, Birmingham Heartlands Hospital, Birmingham B9 5SS, UK
  2. 2Pharmacy Manufacturing Unit, North Staffordshire Hospital, Stoke on Trent ST4 6QG, UK
  3. 3Department of Pharmacy, Birmingham Heartlands Hospital, Birmingham
  1. D J White, Department of Sexual Medicine, Hawthorn House, Heartlands Hospital, Birmingham B9 5SS, UK dwhite{at}hawthorn.co.uk or A R Habib ahabib{at}hawthorn.co.uk

Abstract

Patients with vaginitis due to highly azole resistant Candida glabrata can be particularly difficult to treat. We describe three cases of longstanding vaginal candidiasis due to C glabrata. These had failed to respond to local and systemic antifungals. Flucytosine (1 g) and amphotericin B (100 mg) formulated in lubricating jelly base in a total 8 g delivered dose, was used per vagina once daily for 14 days with significant improvement, both clinically and microbiologically.

  • amphotericin
  • flucytosine
  • Candida glabrata
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