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Progressive intrathoracic lymphadenopathy: EBV associated non-Hodgkin's lymphoma
  1. R F Miller1,
  2. E L Jones2,
  3. M J Duddy3,
  4. M Shahmanesh4
  1. 1Windeyer Institute of Medical Sciences, Royal Free and University College Medical School, University College London, and Mortimer Market Centre, Camden and Islington Community Health Services NHS Trust, London WC1E 6AU, UK
  2. 2Department of Pathology, The Medical School, University of Birmingham, Birmingham B15 2TT, UK
  3. 3Department of Radiology, Selly Oak Hospital, Birmingham B29 6JD, UK
  4. 4Genitourinary Medicine Department, Whittall Street Clinic, Birmingham B4 6DH, UK
  1. Correspondence to:
 Dr M Shahmanesh, Genitourinary Medicine Department, Whittall Street Clinic, Birmingham B4 6DH, UK; 


A 30 year old man presented with late stage HIV disease and intrathoracic lymphadenopathy. Histology of a mediastinal biopsy suggested infective follicular hyperplasia or a peripheral T cell lymphoma. Subsequently, Epstein-Barr virus (EBV) infection was demonstrated in lymphocytes in the biopsy. Later, hepatosplenomegaly and peripheral lymphadenopathy developed. Histology of a cervical lymph node biopsy showed EBV associated diffuse large B cell (non-Hodgkin's) lymphoma.

  • intrathoracic lymphadenopathy
  • Epstein-Barr virus
  • non-Hodgkin's lymphoma

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