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Nevirapine + efavirenz based salvage therapy in heavily pretreated HIV infected patients
  1. J Olivieri
  1. HIV Medical Direct, Greenwich House. Greenwich House, Inc., 80 5th Avenue, New York, NY 10011, USA;

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    The emergence of protease inhibitors (PIs) and multiple drug therapy for HIV infection has greatly decreased mortality in countries where these medications are available. Unfortunately, many patients eventually develop viral resistance to treatment because of HIV virus mutations. As clinicians await development of new drugs to combat resistant virus, innovative strategies with existing drugs may be particularly valuable. Patients having failed regimens containing nucleoside reverse transcriptase inhibitors (NRTIs) and PIs face limited options for future therapy. A regimen containing the two potent non-nucleoside reverse transcriptase inhibitors (NNRTIs), nevirapine (NVP) and efavirenz (EFV), could provide an effective alternative, since both can be conveniently dosed once daily1, 2 and have demonstrated …

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