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Genital herpes serotesting: a study of the epidemiology and patients’ knowledge and attitude among STD clinic attenders in Coventry, UK
  1. N Narouz1,
  2. P S Allan1,
  3. A H Wade1,
  4. S Wagstaffe2
  1. 1Department of Genitourinary Medicine, Coventry and Warwickshire Hospital, Coventry, UK
  2. 2PHLS, Coventry and Warwickshire Hospital, Coventry, UK
  1. Correspondence to:
 Dr Noshi Narouz, Department of GU Medicine, Coventry and Warwickshire Hospital, Coventry CV1 4FH, UK;


Objectives: To examine the seroprevalence and correlates of antibodies to herpes simplex viruses type 1 (HSV-1) and type 2 (HSV-2), and to assess patients’ knowledge and attitude towards genital herpes infection and its serotesting, before and after counselling.

Methods: A cross sectional study among genitourinary medicine (GUM) clinic attenders in Coventry, a UK metropolitan city. Participants were asked to complete a self administered questionnaire before and after counselling. Patients were counselled before testing and after receiving the result. A commercially available enzyme immunoassay (EIA) was used to identify HSV-1 and HSV-2 antibodies (Gull/Meridian EIA).

Results: 223 patients participated in the study (97% of eligible patients). Overall, prevalence of HSV-2 antibody was 43/216 (20%) (19/103, 18% for males and 24/113 (21%) for females, p=0.61) while prevalence of HSV-1 antibody was 129/215 (60%) (60% for both sexes, p=0.91). In the multivariate analysis HSV-2 seropositivity was higher among black people and those with a history of genital herpes. HSV-1 seropositivity was independently associated with less education, increased years of sexual activity (between 14–25 years), and history of cold sores. The majority of patients wanted this serotesting to be available in the clinic (204/222 (92%) before and 216/218 (99%) after counselling, p=0.0003) and 97% accepted the test when offered. Only three patients regretted having the test and four patients contacted the department within 6 months of receiving the results for more counselling.

Conclusion: The vast majority of the study population not only wanted to be tested, but accepted the test when offered. HSV-2 infection is common and largely unrecognised among our study population. The psychological impact of introducing type specific HSV serological testing in a clinical setting seems to be minimal. Counselling could improve patients’ awareness of the infection and the acceptability of the test and its results.

  • genital herpes
  • serotesting
  • seroprevalence
  • attitude
  • knowledge
  • counselling

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