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  • Central pontine myelinolysis complicating treatment of multicentric Castleman’s disease and Kaposi’s sarcoma in a patient with AIDS

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Clinicopathological conference
Central pontine myelinolysis complicating treatment of multicentric Castleman’s disease and Kaposi’s sarcoma in a patient with AIDS
  1. A Apoola1,
  2. J Ross1,
  3. M J Duddy2,
  4. V Mudaliar3,
  5. E L Jones3,
  6. M Huengsberg1,
  7. R F Miller4
  1. 1Department of Genitourinary Medicine, Whittall Street Clinic, Birmingham B4 6DH, UK
  2. 2Department of Radiology, University Hospital Birmingham, Selly Oak Hospital, Birmingham B29 6JD, UK
  3. 3Department of Pathology, The Medical School, University of Birmingham B15 2TT, UK
  4. 4Department of Sexually Transmitted Diseases, Windeyer Institute of Medical Sciences, Royal Free and University College Medical School, University College London and Mortimer Market Centre, Camden PCT, London WC1E 6AU, UK
  1. Correspondence to:
 Dr J Ross, Department of Genitourinary Medicine, Whittall Street Clinic, Birmingham B4 6DH, UK; 
 jonathan.ross{at}hobtpct.nhs.uk

Abstract

An HIV positive black African woman presented with widespread lymphadenopathy and pancytopenia that had been ascribed to tuberculosis. Lymph node biopsy showed both Kaposi’s sarcoma and multicentric Castleman’s disease. Despite antiretroviral therapy and chemotherapy the patient deteriorated, developing confusion and dysphasia. A cranial magnetic resonance scan showed central pontine myelinolysis. Despite supportive therapy the patient died.

  • pontine myelinolysis
  • Castleman’s disease
  • Kaposi’s sarcoma
  • AIDS

https://doi.org/10.1136/sti.79.3.179

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