Article Text

See original article:

Download PDFPDF

Chlamydial infection: an accurate model for opportunistic screening in general practice
  1. V Verhoeven,
  2. D Avonts,
  3. A Meheus,
  4. H Goossens,
  5. M Ieven,
  6. S Chapelle,
  7. C Lammens,
  8. P Van Royen
  1. University of Antwerp, Department of General Practice Universiteitsplein 1 Wilrijk, 2610, Belgium
  1. Correspondence to:
    Dr Veronique Verhoeven, University of Antwerp, Department of General Practice, Universiteitsplein 1 Wilrijk, 2610, Belgium;
    verover{at}uia.ua.ac.be

Abstract

Objectives: To estimate the prevalence of Chlamydia trachomatis in women in general practice and to assess risk factors associated with infection.

Methods: The study was carried out in 2001–2 in different general practices in Antwerp, Belgium. Sexually active women, visiting their general practitioner for routine gynaecological care (mostly pill prescription or PAP smear), were offered opportunistic screening for chlamydia. 787 participants aged 15–40 delivered a self taken vaginal sample and filled in a questionnaire which included questions on demographic variables, urogenital symptoms, sexual history, and sexual behaviour. Samples were tested for presence of chlamydial DNA by means of a ligase chain reaction (LCR) assay, and positives were confirmed by two other amplification assays (PCR and SDA).

Results: Overall prevalence was 5.0% (95% CI: 3.5 to 6.5). Determinants of infection in logistic regression analysis were age 18–27 years, >1 partner in the past year, no use of contraceptives, frequent postcoital bleeding, having a symptomatic partner, painful micturition, and living in the inner city. The area under the ROC curve in the full model was 0.88. Selective screening based on a combination of the five first determinants detects 92.3% of infections in this sample; 37.5% of the population would need to be screened.

Conclusion: Targeted screening for chlamydial infection is possible, even in a heterogeneous group of general practice attendants. Implementing this model would require considerable communication skills from healthcare providers.

  • general practice
  • screening
  • Chlamydia trachomatis
View Full Text

Statistics from Altmetric.com

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Linked Articles

  • Correction
    BMJ Publishing Group Ltd