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Tetracycline treatment does not eradicate Mycoplasma genitalium
  1. L Falk1,
  2. H Fredlund2,
  3. J S Jensen3
  1. 1Department of Dermatology and Venereology, Örebro University Hospital, Örebro, Sweden
  2. 2Department of Clinical Microbiology and Immunology, Örebro University Hospital, Örebro, Sweden
  3. 3Statens Serum Institut, Mycoplasma Laboratory, Copenhagen, Denmark
  1. Correspondence to:
    Lars Falk, Department of Dermatology and Venereology, Örebro University Hospital, SE-701 85 Örebro, Sweden;


Objectives: To study the treatment efficacy of tetracyclines and azithromycin in Mycoplasma genitalium positive patients attending an STD clinic.

Methods: All M genitalium positive patients (34 men and 26 women) attending an STD clinic during a 6 month period were treated with antibiotics. All patients known to be partners of M genitalium positive patients and those who were M genitalium positive, but not initially treated, were treated with azithromycin. Patients with urethritis and/or cervicitis were treated with tetracyclines before their M genitalium status was known.

Results: 10 of 14 women (71%) and 10 of 16 men (63%) treated with tetracyclines were M genitalium positive at follow up, whereas all patients treated with azithromycin (16 men and 20 women) were M genitalium negative, at the 4 week follow up visit.

Conclusions: These results suggest that tetracyclines are not sufficient to eradicate M genitalium. Randomised controlled treatment trials are urgently needed.

  • sexually transmitted diseases
  • Mycoplasma infections
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