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Emerging of dual AIDS associated neoplastic diseases in the era of highly active antiretroviral therapy
  1. R Manfredi,
  2. L Calza,
  3. F Chiodo
  1. Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna “Alma Mater Studiorum”, S. Orsola Hospital, Bologna, Italy
  1. Correspondence to:
    Dr Roberto Manfredi, Department of Clinical and Experimental Medicine, Division of Infectious Diseases, University of Bologna, S Orsola Hospital, Via Massarenti 11, I-40138 Bologna, Italy;
    manfredi{at}med.unibo.it

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Kaposi’s sarcoma, non-Hodgkin’s lymphoma, and cervical cancer remain the only AIDS associated malignancies, according to the 1993 CDC definition, but other neoplasms were reported throughout AIDS pandemic (Hodgkin’s lymphoma, oropharyngeal, oesophageal, gastric, anal, lung, and brain cancer, testicular-ovarian neoplasms, melanoma, skin and thyroid malignancies, multiple myeloma, leiomyosarcomas, angiosarcomas, smooth muscle tumours), with an increasing frequency despite HAART introduction.1–,4

Among 711 AIDS patients notified since 1985, 66 (9.3%) were diagnosed because of an AIDS defining cancer, and 51 more patients (7.2%) developed a malignancy with AIDS, but dual AIDS associated neoplasms were never seen until 2000. A rare combination of lethal Kaposi’s sarcoma plus non-Hodgkin’s lymphoma was recently observed. Two homo/bisexual men had received multiple antiretroviral lines since 1990–2, but complete viral suppression was achieved by the …

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