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Clearance of HPV infection in middle aged men and women after 9 years’ follow up
  1. S de Sanjose1,
  2. F X Bosch1,
  3. L A Tafur2,
  4. C M Nascimento3,
  5. I Izarzugaza4,
  6. A Izquierdo5,
  7. A Barricarte6,
  8. K V Shah7,
  9. C J L M Meijer8,
  10. N Muñoz9
  1. 1Servei d’Epidemiologia i Registre del Càncer, Institut Català d’Oncologia, L’Hospitalet de Llobregat, Spain
  2. 2Universidad del Valle, Cali, Colombia
  3. 3Universidade de Sao Paulo, Brazil
  4. 4Registro de Cancer, Bilbao, Spain
  5. 5Unitat d’ Epidemiologia i Registre de Càncer de Girona, Spain
  6. 6Instituto de Salud Pública. Gobierno de Navarra, Pamplona, Spain
  7. 7The Johns Hopkins School of Public Health, Baltimore, MD, USA
  8. 8Department of Pathology, VU Medical Center, Amsterdam, Netherlands
  9. 9International Agency for Research on Cancer, Lyon, France
  1. Correspondence to:
    Silvia de Sanjosé, Servei d’Epidemiologia i Registre del Cancer, Institut Catala d’Oncologia, Gran Via Km 2.7, E-08907 L’Hospitalet, Barcelona, Spain;

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The age prevalence of human papillomavirus (HPV) cervical infections is high in young age groups, declining sharply thereafter, reaching a steady state after age 40.1 Women who remain persistent carriers of HPV DNA are considered at high risk for cervical cancer. To investigate viral persistence over an extended period of time, we re-contacted, in 1997–8, a group of women who participated in case-control studies between 1988–91 in Spain, Colombia, and Brazil.2–,4 Among women with confirmed normal cervical smears, follow up was scheduled for all women positive …

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