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Comparison of the serological response to treatment of early syphilis in HIV positive versus HIV negative individuals
  1. M A Kingston,
  2. S P Higgins
  1. Department of Genitourinary Medicine, North Manchester General Hospital, Manchester M8 5RB, UK
  1. Correspondence to:
 Dr M A Kingston
 Department of Genitourinary Medicine, North Manchester General Hospital, Delaunays Road, Crumpsall, Manchester M8 5RB, UK; davemagsntlworldcom

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The effectiveness of treatment for syphilis is evaluated by demonstrating declining titres of the non-treponemal antibody tests—for example, the rapid plasma reagin (RPR). The serological response in HIV co-infected individuals has been the subject of debate, with some studies reporting a similar serological response1,2 and others a delayed response in HIV positive patients.3,4

A resurgence of infectious syphilis has occurred in Manchester, United Kingdom, in recent years.5 From January 1999 to August 2002, 379 cases of early syphilis were reported and 28% were HIV co-infected (CDSC North West, personal communication). North Manchester General Hospital (NMGH) houses one of the city’s three genitourinary medicine …

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