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The prevalence of Neisseria gonorrhoeae negative for proline iminopeptidase in Asturias, Spain
  1. L Otero1,
  2. M Alvarez-Argüelles2,
  3. H Villar3,
  4. J Díaz-Gigante4,
  5. F Carreño5,
  6. F Vázquez5,6
  1. 1S. Microbiología, Hospital de Cabueñes, Gijón, Spain
  2. 2S. Microbiología, Hospital Central de Asturias, Oviedo, Spain
  3. 3S. Microbiología, Hospital San Agustín, Avilés, Spain
  4. 4S. Microbiología, Hospital de Arriondas, Spain
  5. 5S. Microbiología, Hospital Monte Naranco, Oviedo, Spain
  6. 6Area de Microbiología, Facultad de Medicina, Oviedo, Spain
  1. Correspondence to:
 Fernando Vázquez
 Area de Microbiología, Facultad de Medicina, C/Julían Clavería s/n, 33006 Oviedo, Asturias, Spain; fvazquez{at}

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Alexander et al1 have recently reported the prevalence of Neisseria gonorrhoeae negative for proline iminopeptidase (Pip) in England and Wales. This is a considerable problem given that many commercial biochemical test panels (Gonochek II, API NH or RapidID NH) monitor the presence of this enzyme and generate a false-negative identification.1–3 As data are scarce, we present our findings of the past 4 years.

A total of 143 isolates from consecutive patients were received during a 4-year period (2003–2006) at the Regional Laboratory for Gonococci, Hospital Monte Naranco, Oviedo, Spain. This unit receives all the isolates of N gonorrhoeae in Asturias, a regional county in the north of Spain with a population of …

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  • LO was responsible for initiation of the study and the isolate screening methods; HV, JD-G, MA-A and FC were responsible for the isolate screening methods; FV was responsible for the initiation, supervision and elaboration of the study.

  • Competing interests: None.