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Are serological chlamydia-specific markers useful to detect asymptomatic cases of lymphogranuloma venereum proctitis?
  1. V Smelov1,
  2. S A Morré2,3,4,
  3. H de Vries5,6
  1. 1
    Faculty of Medicine, St Petersburg State University, St Petersburg, Russia
  2. 2
    Department of Pathology, Laboratory of Immunogenetics, Department of Internal Medicine, Section of Infectious Diseases, VU University Medical Center, Amsterdam, The Netherlands
  3. 3
    Department of Medical Microbiology, Academic Hospital Maastricht, Maastricht, The Netherlands
  4. 4
    Department of Infectious Diseases, City of Hope Medical Center and Beckman Research Institute, Duarte, California, USA
  5. 5
    STI outpatient clinic, Cluster Infectious Diseases, Health Service Amsterdam, Amsterdam, The Netherlands
  6. 6
    Department of Dermatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
  1. Henry de Vries, Department of Dermatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; h.j.devries{at}

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Recent reports on lymphogranuloma venereum (LGV) proctitis in men who have sex with men (MSM) have highlighted the fact that affordable diagnostic procedures for both symptomatic as well as asymptomatic LGV infections are urgently needed.1 2 LGV responds well to extensive antibiotic treatment but when untreated, LGV can cause chronic or irreversible complications as a result of severe inflammation and invasive infection.3

In a recent interesting study, van der Snoek et al4 concluded that an elevated Chlamydia trachomatis IgA antibody response and the age of the infected individual are of possible diagnostic value for the early detection of LGV proctitis. Based on their study of 24 MSM with L2 proctitis and 15 MSM with rectal C. trachomatis (non-LGV) infection, the authors suggest that the association between LGV L2 and significantly higher titres of IgA and IgG are caused by more invasive and more chronic …

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  • Competing interests: None declared.

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