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First UK report of successful treatment of Mycobacterium simiae and immune reconstitution inflammatory syndrome in an HIV-seropositive patient
  1. D R Phillips1,
  2. H Krishnan2,
  3. J Watson3
  1. 1
    Courtyard Clinic, St George’s Hospital NHS Trust, London, UK
  2. 2
    Department of Histopathology, Mayday University Hospital, Croydon, UK
  3. 3
    Department of GU Medicine, Mayday University Hospital, Croydon, UK
  1. Dr D R Phillips, Department of GU–HIV Medicine, Courtyard Clinic, St George’s Hospital NHS Trust, Blackshaw Road, Tooting, London SW17 0QT, UK; david.phillips{at}


Non-tuberculous mycobacteria (NTM) such as Mycobacterium avium intracellulare are commonly encountered by HIV physicians and management strategies are well established. Experience of other NTM is, however, limited. As HIV epidemiology in the United Kingdom changes, we may expect the emergence of these lesser known mycobacterial infections. We present the first UK report of an AIDS patient who has survived infection with disseminated Mycobacterium simiae despite cerebrospinal fluid involvement, an extremely high level of baseline HIV viraemia and treatment complicated by severe immune reconstitution inflammatory syndrome.

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  • Competing interests: None.

  • Patient consent: Informed consent was obtained for publication of the person’s details in this report.

  • Contributors: DRP reviewed the literature and wrote the case study. HK provided fig 1 and gave histopathology advice. DRP, HK and JW revised and edited the article.