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Commentary on “Chlamydia trachomatis OmpA genotyping as a tool for studying the natural history of genital chlamydial infection”
  1. David Mabey
  1. London School of Hygiene and Tropical Medicine, London, UK
  1. Dr D Mabey, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK; David.mabey{at}

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Geisler et al1 have typed strains of Chlamydia trachomatis from 102 individuals in Alabama who tested positive by culture and/or PCR at baseline, and again when they returned for treatment up to 60 days later, by sequencing the ompA gene. Ninety per cent of the subjects were female and 88% were African American. The most commonly identified genotype was E (28%), as has been found in other studies, followed by D/Da (23%) and J/Ja (19%). Subjects infected with genotype J/Ja were significantly more likely to be culture negative, suggesting that they might have a lower bacterial load than found with other genotypes and …

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  • Funding: David Mabey’s chlamydia research group is funded by the Wellcome Trust and the Bill and Melinda Gates Foundation.

  • Competing interests: None.

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