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Clinical characteristics of bacterial vaginosis among women testing positive for fastidious bacteria
  1. C L Haggerty1,
  2. P A Totten2,
  3. M Ferris3,
  4. D H Martin3,
  5. S Hoferka1,
  6. S G Astete2,
  7. R Ondondo2,
  8. J Norori3,
  9. R B Ness1
  1. 1
    University of Pittsburgh, Pittsburgh, Philadelphia, USA
  2. 2
    Department of Medicine, Division of Infectious Diseases, University of Washington, Seattle, Washington, USA
  3. 3
    Research Institute for Children, Departments of Pediatrics and Microbiology, LSUHSC, New Orleans, Louisiana, USA
  1. Dr C L Haggerty, University of Pittsburgh, Department of Epidemiology, 130 DeSoto Street, 516B Parran Hall, Pittsburgh, PA 15261, USA; haggerty{at}pitt.edu

Abstract

Objectives: As the aetiology of bacterial vaginosis (BV) is not well understood, this study sought to determine the relationships between several fastidious microbes, BV and selected clinical characteristics of BV.

Methods: Endometrial and cervical specimens from 50 women with non-gonococcal, non-chlamydial endometritis were tested for Leptotrichia sanguinegens/amnionii, Atopobium vaginae, bacterial vaginosis-associated bacteria 1 (BVAB1), Ureaplasma urealyticum biovar 2 (UU-2) and Ureaplasma parvum using PCR. BV was categorised using Nugent’s and Amsel’s criteria. Odds ratios (OR) adjusted for age and race were estimated using multivariable logistic regression.

Results: Although elevated pH was a universal feature, other BV characteristics differed by pathogen, suggesting variable clinical presentation. Only UU-2 was strongly associated with vaginal discharge, but a positive whiff test and a 20% or greater classification of epithelial cells as clue cells were more common among women with L sanguinegens/amnionii, A vaginae and BVAB1. For each of these bacteria, there were trends towards associations with BV defined by Amsel’s criteria (L sanguinegens/amnionii OR 2.9, 95% CI 0.5 to 15.7; A vaginae OR 2.6, 95% CI 0.6 to 11.4; BVAB1 OR 5.7, 95% CI 1.0 to 31.1) and significant associations with BV defined by Gram stain (L sanguinegens/amnionii OR 17.7, 95% CI 2.8 to 113.0; A vaginae OR 19.2, 95% CI 3.7 to 98.7; BVAB1 OR 21.1, 95% CI 2.2 to 198.5).

Conclusions: L sanguinegens/amnionii, A vaginae and BVAB1 are associated with clinical characteristics consistent with BV and BV defined by Nugent’s and Amsel’s criteria. These fastidious bacteria may cause unrecognised infection, as none was associated with abnormal vaginal discharge.

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Footnotes

  • See Editorial, p 240

  • Funding: This study was supported by grant no HS08358 from the Agency for Healthcare Research and Quality Development.

  • Competing interests: None.

  • Ethics approval: University of Pittsburgh Institutional Review Board approval was obtained.

  • Patient consent: Obtained.

  • The investigators involved in the PEACH Study include: Antonio Amortegui; Susan L Hendrix; Sharon L Hillier; Robert L Holley; Deborah B Nelson; John Nichols Jr; Jeffrey Peipert; Hugh Randall; Diane Schubeck; Steven J Sondheimer; David E Soper; Richard L Sweet; Wayne Trout; Guiliana Trucco; Harold C Wiesenfeld and Tamer Yalcinkaya.

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