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Are post-treatment follow-up visits at 1 and 2 months necessary in patients treated for early syphilis?
  1. S Day,
  2. K Gedela
  1. John Hunter Clinic, St Stephen’s Centre, Chelsea and Westminster Hospital NHS Foundation Trust, London, UK
  1. Correspondence to S Day, John Hunter Clinic, St Stephen's Centre, Chelsea and Westminister Hospital NHS Foundation Trust, 369 Fulham Road, London, SW10 9NH, UK;{at}

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European and National guidelines stipulate patients with early syphilis should attend for clinical and serological follow-up at 1, 2, 3, 6 and 12 months post-treatment.1 2 Serological follow-up uses the non-treponemal antigen tests—for example, Venereal Disease Research Laboratory (VDRL)—to monitor treatment response and identify if re-infection or treatment failure has occurred. To date, there has been no evidence outlining the need for serological follow-up before 3 months. The Centers for Disease Control and Prevention (CDC) guidelines stipulate follow-up at 6 and 12 months only.3

Clinical follow-up for early syphilis should ensure symptom resolution, compliance with treatment and abstinence from sex coordinated with partner notification/treatment. Similar follow-up for infections such as chlamydia …

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  • Competing interests None.

  • Provenance and Peer review Not commissioned; not externally peer reviewed.