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Case report
Syphilitic periostitis of the skull and ribs in a HIV positive patient
  1. Michael Samarkos1,
  2. Charis Giannopoulou2,
  3. Eleni Karantoni1,
  4. Vassileios Papastamopoulos3,
  5. Ioannis Baraboutis3,
  6. Athanassios Skoutelis1,3
  1. 15th Department of Internal Medicine, Evagelismos Hospital, Athens, Greece
  2. 2Nuclear Medicine Department, Evagelismos Hospital, Athens, Greece
  3. 3Infectious diseases Unit, Evagelismos Hospital, Athens, Greece
  1. Correspondence to Michael Samarkos, 5th Department of Internal Medicine, Evagelismos Hospital, 45 Ipsilantou street, Athens 10676, Greece; msamarkos{at}


We report the case of a HIV and syphilis co-infected patient who presented with headache and rash and was found to have syphilitic periostitis. Our case illustrates a rare manifestation of early syphilis and presents the diagnostic dilemmas that can arise in HIV and syphilis co-infected patients.

  • HIV infections
  • AIDS
  • syphilis
  • periostitis
  • CNS
  • HIV

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  • Competing interests None declared.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.