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Spontaneous remission of sexually transmitted diseases must be considered in randomised controlled trials
  1. Mary Jane Rotheram-Borus1,
  2. Zunyou Wu2,
  3. Li Li1,
  4. Roger Detels1,
  5. Li-Jung Liang1,
  6. and the NIMH Collaborative HIV/STD Prevention Trial Group
  1. 1University of California at Los Angeles, Semel Institute for Neuroscience and Human Behavior, Center for Community Health, Los Angeles, California, USA
  2. 2National Center for AIDS/STD Control and Prevention, Chinese Centers for Disease Control and Prevention, Beijing, China
  1. Correspondence to Dr Mary Jane Rotheram-Borus, University of California, Semel Institute for Neuroscience and Human Behavior, 10920 Wilshire Boulevard, Suite 350, Los Angeles, CA 90024, USA; cchpublications{at}

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Randomised controlled trials that test biomedical interventions to reduce sexually transmitted infections (STIs) have had very mixed results,1 2 as have behavioural trials.3 4 It is only in the past 10 years that the field has recognised that chlamydia resolves itself without treatment in 50% of the cases,4 although the estimates range from 13% to 60%.5–7 The length of time to clear chlamydia infection varies from 60 days in women to up to 15 months in men.5 The speed of resolution is also subject …

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